Analysis Tools
craniofacial
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• total tooth volume is reduced for upper incisors, upper first molars, and lower first molars at P28
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• incisors are variably hypoplastic with pitted labial surfaces at P14 but not at birth
• at P28, incisors continue to exhibit disrupted ameloblast polarity, reduced enamel space, and persistence of immature enamel matrix
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• by P28, enamel is whiter and more translucent
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• molars exhibit increased attrition following eruption such that in some mice by 7 days posteruption (P28), crown wear reaches the dentin in first molars and by P84, molar cusps are worn almost completely flat
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taurodontia
(
J:275989
)
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• root patterning defects include severely taurodontic mandibular second molars
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• mice exhibit defects in molar crown morphology
• crown anomalies are more evident posteruption (P28 and P84)
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• at preeruption strages of P7 and P14, molar cusps are shallower in appearance
• 25% of mice show complete loss of cusp patterning
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• root patterning defects that include severely taurodontic (enlarged pulp chambers, apical displacement of the pulpal floor, reduced separation or fusion of mesial and distal roots, and reduced constriction at the cementum-enamel junction) mandibular second molars and peg-shaped mandibular first molar roots
• C-shaped roots in mandibular second molars
• single canal in single-rooted mandibular first molars
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• 3 mice have missing mandibular third molars unilaterally and 1 is missing a maxillary third molar
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• the enamel matrix layer is reduced
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• P28 mice exhibit a more radiolucent enamel layer in immature stages of amelogenesis and a more incisally located transition from immature to mature enamel indicating delayed enamel maturation
|
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• aberrant ameloblast organization and function
• the ameloblast layer appears ragged and discontinuous at P7
• molar ameloblasts appear less organized, with increased space between cells at P14
• ameloblasts appear to persist in the secretory stage as compared with the shorter mature ameloblasts in incisors
|
|
• mandibular molars exhibit decreased enamel mineral density prior to eruption (P14)
• however, at posteruption stages, the enamel mineral density recovers to levels seen in heterozygous Cre mice but is still less than in wild-type controls
• however, dentin density, percentage dentin volume, and percentage enamel volume are normal
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• shearing of enamel rods is seen in P28 mice
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• mice exhibit thinner mandibular incisor enamel, particularly at P14
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• two mice have supernumerary teeth, one with an extra mandibular incisor and one with a diastema tooth
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• epithelial morphology is perturbed in Hertwigs epithelial root sheath, which appears shortened
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growth/size/body
|
• total tooth volume is reduced for upper incisors, upper first molars, and lower first molars at P28
|
|
• incisors are variably hypoplastic with pitted labial surfaces at P14 but not at birth
• at P28, incisors continue to exhibit disrupted ameloblast polarity, reduced enamel space, and persistence of immature enamel matrix
|
|
• by P28, enamel is whiter and more translucent
|
|
• molars exhibit increased attrition following eruption such that in some mice by 7 days posteruption (P28), crown wear reaches the dentin in first molars and by P84, molar cusps are worn almost completely flat
|
taurodontia
(
J:275989
)
|
• root patterning defects include severely taurodontic mandibular second molars
|
|
• mice exhibit defects in molar crown morphology
• crown anomalies are more evident posteruption (P28 and P84)
|
|
• at preeruption strages of P7 and P14, molar cusps are shallower in appearance
• 25% of mice show complete loss of cusp patterning
|
|
• root patterning defects that include severely taurodontic (enlarged pulp chambers, apical displacement of the pulpal floor, reduced separation or fusion of mesial and distal roots, and reduced constriction at the cementum-enamel junction) mandibular second molars and peg-shaped mandibular first molar roots
• C-shaped roots in mandibular second molars
• single canal in single-rooted mandibular first molars
|
|
• 3 mice have missing mandibular third molars unilaterally and 1 is missing a maxillary third molar
|
|
• the enamel matrix layer is reduced
|
|
• P28 mice exhibit a more radiolucent enamel layer in immature stages of amelogenesis and a more incisally located transition from immature to mature enamel indicating delayed enamel maturation
|
|
• aberrant ameloblast organization and function
• the ameloblast layer appears ragged and discontinuous at P7
• molar ameloblasts appear less organized, with increased space between cells at P14
• ameloblasts appear to persist in the secretory stage as compared with the shorter mature ameloblasts in incisors
|
|
• mandibular molars exhibit decreased enamel mineral density prior to eruption (P14)
• however, at posteruption stages, the enamel mineral density recovers to levels seen in heterozygous Cre mice but is still less than in wild-type controls
• however, dentin density, percentage dentin volume, and percentage enamel volume are normal
|
|
• shearing of enamel rods is seen in P28 mice
|
|
• mice exhibit thinner mandibular incisor enamel, particularly at P14
|
|
• two mice have supernumerary teeth, one with an extra mandibular incisor and one with a diastema tooth
|
|
• epithelial morphology is perturbed in Hertwigs epithelial root sheath, which appears shortened
|
skeleton
|
• total tooth volume is reduced for upper incisors, upper first molars, and lower first molars at P28
|
|
• incisors are variably hypoplastic with pitted labial surfaces at P14 but not at birth
• at P28, incisors continue to exhibit disrupted ameloblast polarity, reduced enamel space, and persistence of immature enamel matrix
|
|
• by P28, enamel is whiter and more translucent
|
|
• molars exhibit increased attrition following eruption such that in some mice by 7 days posteruption (P28), crown wear reaches the dentin in first molars and by P84, molar cusps are worn almost completely flat
|
taurodontia
(
J:275989
)
|
• root patterning defects include severely taurodontic mandibular second molars
|
|
• mice exhibit defects in molar crown morphology
• crown anomalies are more evident posteruption (P28 and P84)
|
|
• 25% of mice show complete loss of cusp patterning
• at preeruption strages of P7 and P14, molar cusps are shallower in appearance
|
|
• root patterning defects that include severely taurodontic (enlarged pulp chambers, apical displacement of the pulpal floor, reduced separation or fusion of mesial and distal roots, and reduced constriction at the cementum-enamel junction) mandibular second molars and peg-shaped mandibular first molar roots
• C-shaped roots in mandibular second molars
• single canal in single-rooted mandibular first molars
|
|
• 3 mice have missing mandibular third molars unilaterally and 1 is missing a maxillary third molar
|
|
• the enamel matrix layer is reduced
|
|
• P28 mice exhibit a more radiolucent enamel layer in immature stages of amelogenesis and a more incisally located transition from immature to mature enamel indicating delayed enamel maturation
|
|
• aberrant ameloblast organization and function
• the ameloblast layer appears ragged and discontinuous at P7
• molar ameloblasts appear less organized, with increased space between cells at P14
• ameloblasts appear to persist in the secretory stage as compared with the shorter mature ameloblasts in incisors
|
|
• mandibular molars exhibit decreased enamel mineral density prior to eruption (P14)
• however, at posteruption stages, the enamel mineral density recovers to levels seen in heterozygous Cre mice but is still less than in wild-type controls
• however, dentin density, percentage dentin volume, and percentage enamel volume are normal
|
|
• shearing of enamel rods is seen in P28 mice
|
|
• mice exhibit thinner mandibular incisor enamel, particularly at P14
|
|
• two mice have supernumerary teeth, one with an extra mandibular incisor and one with a diastema tooth
|
|
• epithelial morphology is perturbed in Hertwigs epithelial root sheath, which appears shortened
|
