Phenotypes associated with this allele

• Allele Symbol: Cd99l2^tm1.1Dvst
• Allele Name: targeted mutation 1.1, Dietmar Vestweber
• Allele ID: MGI:6116872
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd99l2^tm1.1Dvst/Cd99l2^tm1.1Dvst Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6	MGI:6147345

Genotype
MGI:6147345

cn1

• Allelic Composition: Cd99l2^tm1.1Dvst/Cd99l2^tm1.1Dvst; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:193021 )

N • wild-type bone marrow-derived leukocyte rolling and tethering within endothelium-specific conditional knockout mouse cremaster venules, 4 h after intrascrotal injection with Il1b

abnormal cellular extravasation ( J:193021 )

• 36.3% reduction in extravasation of wild-type bone marrow-derived neutrophils into endothelium-specific conditional knockout mouse cremaster, 4 h after intrascrotal injection with Il1b

• 43% reduction in extravasation of wild-type bone marrow-derived neutrophils into endothelium-specific conditional knockout mouse peritoneum, 4 h after injection with thioglycollate

hematopoietic system

abnormal cellular extravasation ( J:193021 )

• 36.3% reduction in extravasation of wild-type bone marrow-derived neutrophils into endothelium-specific conditional knockout mouse cremaster, 4 h after intrascrotal injection with Il1b

• 43% reduction in extravasation of wild-type bone marrow-derived neutrophils into endothelium-specific conditional knockout mouse peritoneum, 4 h after injection with thioglycollate

immune system

abnormal cellular extravasation ( J:193021 )

• 36.3% reduction in extravasation of wild-type bone marrow-derived neutrophils into endothelium-specific conditional knockout mouse cremaster, 4 h after intrascrotal injection with Il1b

• 43% reduction in extravasation of wild-type bone marrow-derived neutrophils into endothelium-specific conditional knockout mouse peritoneum, 4 h after injection with thioglycollate

decreased susceptibility to type IV hypersensitivity reaction ( J:193021 )

• reduced delayed-type hypersensitivity (DTH) reaction after injection of DNFB-treated wild-type bone marrow-derived T cells into DNFB-treated endothelium-specific conditional knockout mouse ears: 25% reduced T cell recruitment and 21.5% reduced ear swelling