Phenotypes associated with this allele

• Allele Symbol: Mirc11^tm1Rdhl
• Allele Name: targeted mutation 1, Richard Dahl
• Allele ID: MGI:6117136
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc11^tm1Rdhl/Mirc11^tm1Rdhl	B6.129-Mirc11^tm1Rdhl	MGI:6117257

Genotype
MGI:6117257

hm1

• Allelic Composition: Mirc11^tm1Rdhl/Mirc11^tm1Rdhl
• Genetic Background: B6.129-Mirc11^tm1Rdhl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:243248 )

N • B cells secrete normal IgG levels and respond to antigen in culture

abnormal B cell differentiation ( J:243248 )

• 1.5- to 2-fold increase in Hard fractions B, C, C', D and E

• however, fraction A and F are normal

• enhanced in vivo and ex vivo

increased immature B cell number ( J:243248 )

increased transitional stage T1 B cell number ( J:243248 )

• however, T2 and T3 B cell numbers are normal

increased pro-B cell number ( J:243248 )

increased pre-pro B cell number ( J:243248 )

impaired myelopoiesis ( J:243248 )

increased B cell number ( J:243248 )

• twice as many as in the bone marrow than in wild-type mice

• however, dendritic cells and NK progenitor cell numbers are not increased

increased mature B cell number ( J:243248 )

• 1.7-fold in the spleen

increased follicular B cell number ( J:243248 )

• 1.8-fold

• however, marginal zone B cell numbers are normal

increased plasma cell number ( J:243248 )

• 1.5-fold

hematopoietic system

decreased common myeloid progenitor cell number ( J:243248 )

• in the bone marrow

abnormal B cell differentiation ( J:243248 )

• 1.5- to 2-fold increase in Hard fractions B, C, C', D and E

• however, fraction A and F are normal

• enhanced in vivo and ex vivo

increased immature B cell number ( J:243248 )

increased transitional stage T1 B cell number ( J:243248 )

• however, T2 and T3 B cell numbers are normal

increased pro-B cell number ( J:243248 )

increased pre-pro B cell number ( J:243248 )

impaired myelopoiesis ( J:243248 )

increased common lymphocyte progenitor cell number ( J:243248 )

• 1.5- and 2-fold higher

increased B cell number ( J:243248 )

• twice as many as in the bone marrow than in wild-type mice

• however, dendritic cells and NK progenitor cell numbers are not increased

increased mature B cell number ( J:243248 )

• 1.7-fold in the spleen

increased follicular B cell number ( J:243248 )

• 1.8-fold

• however, marginal zone B cell numbers are normal

increased plasma cell number ( J:243248 )

• 1.5-fold

decreased myeloid cell number ( J:243248 )

• CD11b+ myeloid cells

• in the spleen

• however, there is no bias between monocytes and granulocytes