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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr45tm1.1Tshir
targeted mutation 1.1, Toshihiko Shiroishi
MGI:6117321
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr45tm1.1Tshir/Rr45tm1.1Tshir involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj MGI:6144004
cx2
 		Rr45tm1.1Tshir/Rr45+
Shhtm1Chg/Shh+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/JNCrlj MGI:6144003


Genotype
MGI:6144004
hm1
Allelic
Composition		 Rr45tm1.1Tshir/Rr45tm1.1Tshir
Genetic
Background		 involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr45tm1.1Tshir mutation (2 available); any Rr45 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:148018 )
• all mice die within a few days of birth

craniofacial
abnormal sphenoid bone morphology ( J:148018 )
• cartilage contains a hole likely the pituitary fossa
cleft palate ( J:148018 )
• in 5 of 37 mice

growth/size/body
short soft palate ( J:148018 )
cleft palate ( J:148018 )
• in 5 of 37 mice
abnormal tongue morphology ( J:148018 )
meteorism ( J:148018 )
• air in stomach and bowels

digestive/alimentary system
cleft palate ( J:148018 )
• in 5 of 37 mice
abnormal epiglottis morphology ( J:148018 )
• loss or reduced size
meteorism ( J:148018 )
• air in stomach and bowels

behavior/neurological

respiratory system
abnormal epiglottis morphology ( J:148018 )
• loss or reduced size

skeleton
abnormal sphenoid bone morphology ( J:148018 )
• cartilage contains a hole likely the pituitary fossa
abnormal epiglottis morphology ( J:148018 )
• loss or reduced size




Genotype
MGI:6144003
cx2
Allelic
Composition		 Rr45tm1.1Tshir/Rr45+
Shhtm1Chg/Shh+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr45tm1.1Tshir mutation (2 available); any Rr45 mutation (2 available)
Shhtm1Chg mutation (2 available); any Shh mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton

respiratory system

digestive/alimentary system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory