About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcdh19tm1Tac
targeted mutation 1, Taconic
MGI:6117336
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pcdh19tm1Tac/Pcdh19tm1Tac involves: 129S/SvEv * C57BL/6 MGI:6117338
ht2
 		Pcdh19tm1Tac/Pcdh19+ involves: 129S/SvEv * C57BL/6 MGI:6117339
ht3
 		Pcdh19tm1Tac/Pcdh19em1Pqt involves: 129S/SvEv * C57BL/6 MGI:6117341
ot4
 		Pcdh19tm1Tac/Y involves: 129S/SvEv * C57BL/6 MGI:6117340


Genotype
MGI:6117338
hm1
Allelic
Composition		 Pcdh19tm1Tac/Pcdh19tm1Tac
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19tm1Tac mutation (0 available); any Pcdh19 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:256961 , J:255320 )
N
• despite expression patterns, brain structure appears normal and cells are located in the expected locations (J:256961)
• electrocorticograms are indistinguishable from wild-type controls at P42 (J:255320)
abnormal neuronal migration ( J:256961 )
• neurons in cultured neurospheres show increased migration

behavior/neurological
behavior/neurological phenotype ( J:256961 )
N
• no spontaneous seizures detected after weaning

cellular
abnormal neuronal migration ( J:256961 )
• neurons in cultured neurospheres show increased migration




Genotype
MGI:6117339
ht2
Allelic
Composition		 Pcdh19tm1Tac/Pcdh19+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19tm1Tac mutation (0 available); any Pcdh19 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:256961 )
N
• despite expression patterns, brain structure appears normal and cells are located in the expected locations
abnormal brain wave pattern ( J:255320 )
• at P42, electrocorticogram show increase in amplitude, increase in mean number of spike wave discharge events per hour, and increase in duration of spike wave discharge events compared to either homozygous null or wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:256961 )
N
• no spontaneous seizures detected after weaning




Genotype
MGI:6117341
ht3
Allelic
Composition		 Pcdh19tm1Tac/Pcdh19em1Pqt
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19em1Pqt mutation (0 available); any Pcdh19 mutation (7 available)
Pcdh19tm1Tac mutation (0 available); any Pcdh19 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal forebrain development ( J:255320 )
• protein expressing and null cells form distinct clusters in an alternating pattern from the ventricular zone to the cortical plate
• cell segregation is detected at E10.5 but not at E9.5




Genotype
MGI:6117340
ot4
Allelic
Composition		 Pcdh19tm1Tac/Y
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdh19tm1Tac mutation (0 available); any Pcdh19 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:256961 )
N
• despite expression patterns, brain structure appears normal and cells are located in the expected locations
abnormal neuronal migration ( J:256961 )
• neurons in cultured neurospheres show increased migration

behavior/neurological
behavior/neurological phenotype ( J:256961 )
N
• no spontaneous seizures detected after weaning

cellular
abnormal neuronal migration ( J:256961 )
• neurons in cultured neurospheres show increased migration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory