Analysis Tools
mortality/aging
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• 43 of 53 mice die at birth
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• most of the 10 survivors die by P14
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respiratory system
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• 43 of 53 die from respiratory failure after cesarean section
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growth/size/body
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• severe dwarfism at P7 and P14
|
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• similar body weight at birth but decreased by 50% at P7 and P14
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skeleton
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• in tibial growth plates at E18.5 and P14
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• in tibial growth plates at E18.5 and P14
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• at E18.5
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short tibia
(
J:256718
)
|
• at E18.5
|
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• smaller
|
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• Safranin-O staining indicates drastically decreased glycosaminoglycan content
• severely reduced chondroitin sulfate content
|
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• drastically disrupted at P14
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• drastically disrupted at P14
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• at P14 proliferating chondrocytes in long bones are round and lack the longitudinal organization seen in controls
• some chondrocytes with a flat shape are seen outside the proliferative zone
|
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• delayed formation of secondary ossification centers
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cellular
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• in tibial growth plates at E18.5 and P14
|
|
• in tibial growth plates at E18.5 and P14
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limbs/digits/tail
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• at E18.5
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short tibia
(
J:256718
)
|
• at E18.5
|
