Phenotypes associated with this allele

• Allele Symbol: Csgalnact1^tm1Nari
• Allele Name: targeted mutation 1, Hisashi Narimatsu
• Allele ID: MGI:6117384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Csgalnact1^tm1Nari/Csgalnact1^tm1Nari Csgalnact2^tm1.1Staka/Csgalnact2^tm1.1Staka Tg(Col2a1-cre)1Bhr/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:6117390

Genotype
MGI:6117390

cn1

• Allelic Composition: Csgalnact1^tm1Nari/Csgalnact1^tm1Nari; Csgalnact2^tm1.1Staka/Csgalnact2^tm1.1Staka; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:256718 )

• 43 of 53 mice die at birth

postnatal lethality, incomplete penetrance ( J:256718 )

• most of the 10 survivors die by P14

respiratory system

respiratory failure ( J:256718 )

• 43 of 53 die from respiratory failure after cesarean section

growth/size/body

decreased body size ( J:256718 )

• severe dwarfism at P7 and P14

decreased body weight ( J:256718 )

• similar body weight at birth but decreased by 50% at P7 and P14

skeleton

increased chondrocyte apoptosis ( J:256718 )

• in tibial growth plates at E18.5 and P14

decreased chondrocyte proliferation ( J:256718 )

• in tibial growth plates at E18.5 and P14

short humerus ( J:256718 )

• at E18.5

short tibia ( J:256718 )

• at E18.5

thin long bone epiphysis ( J:256718 )

• smaller

abnormal cartilage morphology ( J:256718 )

• Safranin-O staining indicates drastically decreased glycosaminoglycan content

• severely reduced chondroitin sulfate content

abnormal long bone epiphyseal plate proliferative zone ( J:256718 )

• drastically disrupted at P14

abnormal long bone hypertrophic chondrocyte zone ( J:256718 )

• drastically disrupted at P14

abnormal chondrocyte morphology ( J:256718 )

• at P14 proliferating chondrocytes in long bones are round and lack the longitudinal organization seen in controls

• some chondrocytes with a flat shape are seen outside the proliferative zone

abnormal endochondral bone ossification ( J:256718 )

• delayed formation of secondary ossification centers

cellular

increased chondrocyte apoptosis ( J:256718 )

• in tibial growth plates at E18.5 and P14

decreased chondrocyte proliferation ( J:256718 )

• in tibial growth plates at E18.5 and P14

limbs/digits/tail

short humerus ( J:256718 )

• at E18.5

short tibia ( J:256718 )

• at E18.5