Phenotypes associated with this allele

• Allele Symbol: Csgalnact2^tm1.2Staka
• Allele Name: targeted mutation 1.2, Satoru Takahashi
• Allele ID: MGI:6117386
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csgalnact2^tm1.2Staka/Csgalnact2^tm1.2Staka	involves: C57BL/6J	MGI:6117387
cx2	Csgalnact1^tm1.1Nari/Csgalnact1^tm1.1Nari Csgalnact2^tm1.2Staka/Csgalnact2^tm1.2Staka	involves: C57BL/6J	MGI:6117388

Genotype
MGI:6117387

hm1

• Allelic Composition: Csgalnact2^tm1.2Staka/Csgalnact2^tm1.2Staka
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:256718 )

• viable and fertile with no gross abnormalities and normal skeletal morphology

Genotype
MGI:6117388

cx2

• Allelic Composition: Csgalnact1^tm1.1Nari/Csgalnact1^tm1.1Nari; Csgalnact2^tm1.2Staka/Csgalnact2^tm1.2Staka
• Genetic Background: involves: C57BL/6J

mortality/aging

neonatal lethality, complete penetrance ( J:256718 )

• do not survive after birth

respiratory system

respiratory distress ( J:256718 )

• when delivered by cesarean section pups struggle to initiate breathing

respiratory failure ( J:256718 )

• no alveolar air spaces in the lungs indicating mice die of respiratory failure

homeostasis/metabolism

cyanosis ( J:256718 )

growth/size/body

decreased birth body size ( J:256718 )

decreased birth weight ( J:256718 )

• slightly lower

skeleton

short humerus ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote

short tibia ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote

abnormal cartilage morphology ( J:256718 )

• Safranin-O staining indicates drastically decreased glycosaminoglycan content

limbs/digits/tail

short humerus ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote

short tibia ( J:256718 )

• length is reduced by 22% compared to controls

• decreased bone length is not seen in either single homozygote