Phenotypes associated with this allele

• Allele Symbol: Edil3^Tg(lacZ)1Tq
• Allele Name: transgene insertion 1, Thomas Quertermous
• Allele ID: MGI:6117667
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Edil3^Tg(lacZ)1Tq/Edil3^Tg(lacZ)1Tq	Not Specified	MGI:6251493

Genotype
MGI:6251493

hm1

• Allelic Composition: Edil3^Tg(lacZ)1Tq/Edil3^Tg(lacZ)1Tq
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal pinna cartilage morphology ( J:254384 )

♂ • 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

floppy ears ( J:254384 )

♂ • floppy ears that are most noticeable in the first week of life, however ear size is normal

immune system

increased susceptibility to induced arthritis ( J:254384 )

♂ • mice exhibit increased susceptibility to osteoarthritis caused by medial menisectomy to destabilize the knee, showing worse destruction of the medial articular surface of the tibia and femur

♂ • however, no difference in angiogenesis or inflammation is seen in the injured joint following medial menisectomy

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:254384 )

♂ • primary chondrocytes from joints are more susceptible to TNF-alpha/actinomycin D induced apoptosis than wild-type chondrocytes

skeleton

skeleton phenotype ( J:254384 )

♂N • mice exhibit normal bone density and bony skeleton morphology

increased chondrocyte apoptosis ( J:254384 )

♂ • mice show increased number of apoptotic chondrocytes on the medial tibial and femoral articular surfaces of knees after medial menisectomy

♂ • primary chondrocytes from joints are more susceptible to TNF-alpha/actinomycin D induced apoptosis than wild-type chondrocytes

abnormal pinna cartilage morphology ( J:254384 )

♂ • 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

increased susceptibility to induced arthritis ( J:254384 )

♂ • mice exhibit increased susceptibility to osteoarthritis caused by medial menisectomy to destabilize the knee, showing worse destruction of the medial articular surface of the tibia and femur

♂ • however, no difference in angiogenesis or inflammation is seen in the injured joint following medial menisectomy

abnormal articular cartilage morphology ( J:254384 )

♂ • thickness of the knee articular cartilage is reduced by 10-15%

♂ • however, cartilage is biomechanically similar to wild-type cartilage

cellular

increased chondrocyte apoptosis ( J:254384 )

♂ • mice show increased number of apoptotic chondrocytes on the medial tibial and femoral articular surfaces of knees after medial menisectomy

♂ • primary chondrocytes from joints are more susceptible to TNF-alpha/actinomycin D induced apoptosis than wild-type chondrocytes

craniofacial

abnormal pinna cartilage morphology ( J:254384 )

♂ • 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

floppy ears ( J:254384 )

♂ • floppy ears that are most noticeable in the first week of life, however ear size is normal

hearing/vestibular/ear

abnormal pinna cartilage morphology ( J:254384 )

♂ • 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

floppy ears ( J:254384 )

♂ • floppy ears that are most noticeable in the first week of life, however ear size is normal