All Phenotypes Edil3<Tg(lacZ)1Tq> MGI Mouse

abnormal pinna cartilage morphology ( J:254384 )

• 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

floppy ears ( J:254384 )

• floppy ears that are most noticeable in the first week of life, however ear size is normal

increased susceptibility to induced arthritis ( J:254384 )

• mice exhibit increased susceptibility to osteoarthritis caused by medial menisectomy to destabilize the knee, showing worse destruction of the medial articular surface of the tibia and femur

• however, no difference in angiogenesis or inflammation is seen in the injured joint following medial menisectomy

increased physiological sensitivity to xenobiotic ( J:254384 )

• primary chondrocytes from joints are more susceptible to TNF-alpha/actinomycin D induced apoptosis than wild-type chondrocytes

skeleton phenotype ( J:254384 )

N	• mice exhibit normal bone density and bony skeleton morphology

increased chondrocyte apoptosis ( J:254384 )

• mice show increased number of apoptotic chondrocytes on the medial tibial and femoral articular surfaces of knees after medial menisectomy

• primary chondrocytes from joints are more susceptible to TNF-alpha/actinomycin D induced apoptosis than wild-type chondrocytes

abnormal pinna cartilage morphology ( J:254384 )

• 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

increased susceptibility to induced arthritis ( J:254384 )

• mice exhibit increased susceptibility to osteoarthritis caused by medial menisectomy to destabilize the knee, showing worse destruction of the medial articular surface of the tibia and femur

• however, no difference in angiogenesis or inflammation is seen in the injured joint following medial menisectomy

abnormal articular cartilage morphology ( J:254384 )

• thickness of the knee articular cartilage is reduced by 10-15%

• however, cartilage is biomechanically similar to wild-type cartilage

increased chondrocyte apoptosis ( J:254384 )

• mice show increased number of apoptotic chondrocytes on the medial tibial and femoral articular surfaces of knees after medial menisectomy

• primary chondrocytes from joints are more susceptible to TNF-alpha/actinomycin D induced apoptosis than wild-type chondrocytes

abnormal pinna cartilage morphology ( J:254384 )

• 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

floppy ears ( J:254384 )

• floppy ears that are most noticeable in the first week of life, however ear size is normal

abnormal pinna cartilage morphology ( J:254384 )

• 10 week old mice show a 10% decrease in the thickness of the auricular cartilage

floppy ears ( J:254384 )

• floppy ears that are most noticeable in the first week of life, however ear size is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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