Phenotypes associated with this allele

• Allele Symbol: Cemip^tm1.1Tac
• Allele Name: targeted mutation 1.1, Taconic
• Allele ID: MGI:6117713
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cemip^tm1.1Tac/Cemip^tm1.1Tac Tg(Plp1-cre/ERT)3Pop/0	involves: C57BL/6 * C57BL/6NTac * DBA/2	MGI:6117717
cn2	Cemip^tm1.1Tac/Cemip^tm1.1Tac Tg(Dhh-cre)1Mejr/0	involves: C57BL/6NTac * FVB/N	MGI:6117715

Genotype
MGI:6117717

cn1

• Allelic Composition: Cemip^tm1.1Tac/Cemip^tm1.1Tac; Tg(Plp1-cre/ERT)3Pop/0
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Schwann cell physiology ( J:244311 )

• tamoxifen-treated myelinated Schwann cells in culture exhibit reduced dedifferentiation compared with wild-type cells

Genotype
MGI:6117715

cn2

• Allelic Composition: Cemip^tm1.1Tac/Cemip^tm1.1Tac; Tg(Dhh-cre)1Mejr/0
• Genetic Background: involves: C57BL/6NTac * FVB/N

nervous system

abnormal myelination ( J:244311 )

• transient acceleration of postnatal myelination

• however, adult myelination is normal

homeostasis/metabolism

abnormal response to injury ( J:244311 )

• following nerve axotomy or sciatic nerve crush, mice exhibit reduced myelin degradation and increases remyelination compared with wild-type mice

• however, sciatic function index and Von Frey threshold are normal after nerve crush