Phenotypes associated with this allele

• Allele Symbol: Cept1^tm1.1Sem
• Allele Name: targeted mutation 1.1, Clay F Semenkovich
• Allele ID: MGI:6117770
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cept1^tm1.1Sem/Cept1^tm1.1Sem Tg(ACTA1-cre)79Jme/0	involves: C57BL/6J * SJL	MGI:6119503

Genotype
MGI:6119503

cn1

• Allelic Composition: Cept1^tm1.1Sem/Cept1^tm1.1Sem; Tg(ACTA1-cre)79Jme/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:249456 )

N • circulating metabolite levels when fed high fat diet

N • insulin suppression of endogenous hepatic glucose production (HGP suppression) high fat diet fed mice

N • serum free fatty acids, adiponectin and leptin concentrations high fat diet fed mice

N • metabolic rate of high fat diet fed mice

N • body temperature during cold tolerance test of high fat diet fed mice

decreased circulating glucose level ( J:249456 )

• after insulin administration when fed high fat diet

increased respiratory quotient ( J:249456 )

• during dark cycle when fed high fat diet

improved glucose tolerance ( J:249456 )

• when fed high fat diet

• increase in insulin-stimulated 2-deoxyglucose (2DG) uptake by soleus muscles isolated from high fat diet fed mice

increased insulin sensitivity ( J:249456 )

• lower blood glucose after insulin administration when fed high fat diet

• twofold greater glucose infusion rate in hyperinsulinemic-euglycemic clamp tests of high fat diet fed mice

• twofold greater insulin-stimulated glucose disposal rate (IS-GDR) in hyperinsulinemic-euglycemic clamp tests of high fat diet fed mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:249456 )

• decreased performance (running time and distance) of high fat diet fed mice during high-intensity exercise tests

decreased grip strength ( J:249456 )

• in forelimbs of high fat diet fed mice

cellular

cellular phenotype ( J:249456 )

N • protein content of mitochondrial respiration complex I-V, gene expression of mitochondrial biogenesis markers and levels of fatty acid oxidation in gastrocnemius muscles of high fat diet fed mice

N • diacylglycerol (DAG) content, ATP content and mitochondrial density (as determined by electron microscopy) in muscles of high fat diet fed mice

abnormal cellular respiration ( J:249456 )

• reduced phosphatidylethanolamine (PE) in sarcoplasmic reticulum of gastrocnemius muscles of high fat diet fed mice

• increased levels of several phosphatidylcholine (PC) species in sarcoplasmic reticulum of gastrocnemius muscles of high fat diet fed mice

• reduced sarco/endoplasmic Ca2+ ATPase (SERCA) activity in sarcoplasmic reticulum of gastrocnemius muscles of high fat diet fed mice

muscle

muscle weakness ( J:249456 )

• in forelimbs of high fat diet fed mice

• decreased running time and distance of high fat diet fed mice during high-intensity exercise tests

growth/size/body

growth/size/body region phenotype ( J:249456 )

N • body weight and composition, tissue weights when fed high fat diet

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:249456 )

N • hormones levels when fed high fat diet