mortality/aging
• embryos do not survive beyond E9.5
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embryo
• underdeveloped pharyngeal arch structures
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• E9.5 embryos exhibit severe developmental delays
• however, a vascularized yolk sac is seen indicating blood cell formation
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• embryos lack prominent forelimb bud
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• open rostral neural tube at E9.5
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growth/size/body
• E9.5 embryos exhibit severe developmental delays
• however, a vascularized yolk sac is seen indicating blood cell formation
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limbs/digits/tail
• embryos lack prominent forelimb bud
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nervous system
• open rostral neural tube at E9.5
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craniofacial
• underdeveloped pharyngeal arch structures
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