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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lacc1em1Arkr
endonuclease-mediated mutation 1, Arthur Kaser
MGI:6117843
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lacc1em1Arkr/Lacc1em1Arkr C57BL/6NTac-Lacc1em1Arkr MGI:6118079


Genotype
MGI:6118079
hm1
Allelic
Composition		 Lacc1em1Arkr/Lacc1em1Arkr
Genetic
Background		 C57BL/6NTac-Lacc1em1Arkr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lacc1em1Arkr mutation (0 available); any Lacc1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:244365 )
• macrophages exhibit increased basal or maximal uncontrolled oxygen consumption rate compared with wild-type cells
• macrophages exhibit an increased in glycolysis compared with wild-type mice

homeostasis/metabolism

cellular

hematopoietic system
abnormal macrophage physiology ( J:244365 )
• macrophages exhibit increased basal or maximal uncontrolled oxygen consumption rate compared with wild-type cells
• macrophages exhibit an increased in glycolysis compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory