Phenotypes associated with this allele

• Allele Symbol: Eif2s3y^em#Asah
• Allele Name: endonuclease-mediated mutation, Hiroshi Asahara
• Allele ID: MGI:6117849
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	X/Eif2s3y^em#Asah	involves: C57BL/6 * DBA/2	MGI:6118058

Genotype
MGI:6118058

ot1

• Allelic Composition: X/Eif2s3y^em#Asah
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:244443 )

♂N • normal epididymis morphology at age 4 months

azoospermia ( J:244443 )

♂ • at age 4 months

abnormal spermatogonia proliferation ( J:244443 )

♂ • no sperm in testes at age 4 months

♂ • accumulation of Gfra1 (undifferentiated spermatogonia marker) immunoreactive cells at age 4 months

♂ • reduction in number of TRA98 (testicular germ cell marker) immunoreactive cells at age 4 months

decreased testis weight ( J:244443 )

♂ • severely reduced at age 4 months

testis hypoplasia ( J:244443 )

♂ • severely reduced size at age 4 months

male infertility ( J:244443 )

♂

endocrine/exocrine glands

decreased testis weight ( J:244443 )

♂ • severely reduced at age 4 months

testis hypoplasia ( J:244443 )

♂ • severely reduced size at age 4 months

cellular

azoospermia ( J:244443 )

♂ • at age 4 months

abnormal spermatogonia proliferation ( J:244443 )

♂ • no sperm in testes at age 4 months

♂ • accumulation of Gfra1 (undifferentiated spermatogonia marker) immunoreactive cells at age 4 months

♂ • reduction in number of TRA98 (testicular germ cell marker) immunoreactive cells at age 4 months