All Phenotypes Eif2s3y<em2Asah> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eif2s3y^em2Asah
endonuclease-mediated mutation 2, Hiroshi Asahara
MGI:6117853

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	X/Eif2s3y^em2Asah	involves: C57BL/6 * DBA/2	MGI:6118057

Allelic Composition	X/Eif2s3y^em2Asah
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s3y^em2Asah mutation (0 available); any Eif2s3y mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:244443 )

N	• normal epididymis morphology at age 6 months

azoospermia ( J:244443 )

• at age 6 months

abnormal spermatid morphology ( J:244443 )

• spermatids absent according to lack of TRA54 immunoreactivity at age 6 months

abnormal spermatocyte morphology ( J:244443 )

• spermatocytes absent according to lack of TRA54 immunoreactivity at age 6 months

abnormal spermatogonia proliferation ( J:244443 )

• no sperm in testes at age 6 months

• accumulation of Gfra1 (undifferentiated spermatogonia marker) immunoreactive cells at age 6 months

• reduction in number of TRA98 (testicular germ cell marker) immunoreactive cells at age 6 months

decreased testis weight ( J:244443 )

• severely reduced at age 6 months

testis hypoplasia ( J:244443 )

• severely reduced size at age 6 months

male infertility ( J:244443 )

cellular

azoospermia ( J:244443 )

• at age 6 months

abnormal spermatid morphology ( J:244443 )

• spermatids absent according to lack of TRA54 immunoreactivity at age 6 months

abnormal spermatocyte morphology ( J:244443 )

• spermatocytes absent according to lack of TRA54 immunoreactivity at age 6 months

abnormal spermatogonia proliferation ( J:244443 )

• no sperm in testes at age 6 months

• accumulation of Gfra1 (undifferentiated spermatogonia marker) immunoreactive cells at age 6 months

• reduction in number of TRA98 (testicular germ cell marker) immunoreactive cells at age 6 months

endocrine/exocrine glands

decreased testis weight ( J:244443 )

• severely reduced at age 6 months

testis hypoplasia ( J:244443 )

• severely reduced size at age 6 months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24