All Phenotypes Morc2b<tm1Jw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Morc2b^tm1Jw
targeted mutation 1, Jeremy Wang
MGI:6117872

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Morc2b^tm1Jw/Morc2b^tm1Jw	involves: 129S4/SvJae * C57BL/6	MGI:6117873

Allelic Composition	Morc2b^tm1Jw/Morc2b^tm1Jw
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morc2b^tm1Jw mutation (0 available); any Morc2b mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent oocytes ( J:256987 )

• oocytes are present at birth but lost by P2

azoospermia ( J:256987 )

abnormal meiosis ( J:256987 )

• failure of meiotic double strand break repair in spermatocytes

• failure of meiotic recombination

abnormal chromosomal synapsis ( J:256987 )

• failure of chromosomal synapsis in spermatocytes and oocytes

abnormal female meiosis ( J:256987 )

arrest of male meiosis ( J:256987 )

• tubules are devoid of post-meiotic spermatids

increased female germ cell apoptosis ( J:256987 )

• increased apoptosis of oocytes at birth

increased male germ cell apoptosis ( J:256987 )

small ovary ( J:256987 )

small testis ( J:256987 )

decreased testis weight ( J:256987 )

• weigh approximately 70% less than control testes

female infertility ( J:256987 )

male infertility ( J:256987 )

cellular

absent oocytes ( J:256987 )

• oocytes are present at birth but lost by P2

azoospermia ( J:256987 )

abnormal meiosis ( J:256987 )

• failure of meiotic double strand break repair in spermatocytes

• failure of meiotic recombination

abnormal chromosomal synapsis ( J:256987 )

• failure of chromosomal synapsis in spermatocytes and oocytes

abnormal female meiosis ( J:256987 )

arrest of male meiosis ( J:256987 )

• tubules are devoid of post-meiotic spermatids

increased female germ cell apoptosis ( J:256987 )

• increased apoptosis of oocytes at birth

increased male germ cell apoptosis ( J:256987 )

abnormal double-strand DNA break repair ( J:256987 )

• failure of meiotic double strand break repair in spermatocytes

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:256987 )

• failure of meiotic double strand break repair in spermatocytes

endocrine/exocrine glands

small ovary ( J:256987 )

small testis ( J:256987 )

decreased testis weight ( J:256987 )

• weigh approximately 70% less than control testes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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