About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lacc1em2Arkr
endonuclease-mediated mutation 2, Arthur Kaser
MGI:6118040
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lacc1em2Arkr/Lacc1em2Arkr C57BL/6NTac-Lacc1em2Arkr MGI:6118081


Genotype
MGI:6118081
hm1
Allelic
Composition		 Lacc1em2Arkr/Lacc1em2Arkr
Genetic
Background		 C57BL/6NTac-Lacc1em2Arkr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lacc1em2Arkr mutation (0 available); any Lacc1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:244365 )
• macrophages exhibit increased basal or maximal uncontrolled oxygen consumption rate compared with wild-type cells
• macrophages exhibit an increased in glycolysis compared with wild-type mice

homeostasis/metabolism

cellular

hematopoietic system
abnormal macrophage physiology ( J:244365 )
• macrophages exhibit increased basal or maximal uncontrolled oxygen consumption rate compared with wild-type cells
• macrophages exhibit an increased in glycolysis compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory