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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-K1d-em4Dvs
endonuclease-mediated mutation 4, David V Serreze
MGI:6118907
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2-K1d-em4Dvs/H2-K1d-em4Dvs NOD/ShiLtDvs-H2-K1d-em4Dvs/Dvs MGI:6118910


Genotype
MGI:6118910
hm1
Allelic
Composition		 H2-K1d-em4Dvs/H2-K1d-em4Dvs
Genetic
Background		 NOD/ShiLtDvs-H2-K1d-em4Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-K1d-em4Dvs mutation (1 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:257229 )
• insulitis is decreased at 10-15 weeks of age and diabetes onset is delayed and less severe, but not ablated, relative to wild-type
• fewer CD8+ T cells and more CD4+ T cells in the islets than in NOD controls and these CD8+ cells have a higher percentage of CD62L negative/CD44+ effector cells than in NOD controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory