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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pgrmc2tm1.1Jjp
targeted mutation 1.1, John J Peluso
MGI:6118911
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118932
cn2
 		Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118933
cn3
 		Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118934
cn4
 		Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6118935


Genotype
MGI:6118932
cn1
Allelic
Composition		 Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (8 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
early reproductive senescence ( J:247103 )
• 50% of female mice become infertile after the third parity

reproductive system
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
early reproductive senescence ( J:247103 )
• 50% of female mice become infertile after the third parity
abnormal endometrium morphology ( J:247103 )
• breakdown of basement membrane and disruption of epithelial-stromal interface
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium
reduced female fertility ( J:247103 )
• despite normal ovulation, female mice have fewer pups per litter and fewer litters per female compared with control mice
• however, weanling weights are normal
decreased litter size ( J:247103 )
• fewer pups per litter and fewer litters per female

homeostasis/metabolism
decreased circulating progesterone level ( J:247103 )
• marginally at 10.5 days of pregnancy

embryo
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy

immune system
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy

endocrine/exocrine glands
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

hematopoietic system
decreased uterine NK cell number ( J:247103 )
• at 6 days of pregnancy

growth/size/body
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months




Genotype
MGI:6118933
cn2
Allelic
Composition		 Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (8 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

reproductive system
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium




Genotype
MGI:6118934
cn3
Allelic
Composition		 Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2tm1.1Jjp
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (11 available)
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (8 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

reproductive system
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months
abnormal endometrium morphology ( J:247103 )
• breakdown of basement membrane and disruption of epithelial-stromal interface
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium
reduced female fertility ( J:247103 )
• female mice have fewer pups per litter and fewer litters per female compared with control mice
decreased litter size ( J:247103 )
• fewer pups per litter and fewer litters per female

endocrine/exocrine glands
abnormal endometrial gland morphology ( J:247103 )
• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

growth/size/body
uterus cyst ( J:247103 )
• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months




Genotype
MGI:6118935
cn4
Allelic
Composition		 Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp
Pgrmc2tm1.1Jjp/Pgrmc2+
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (11 available)
Pgrmc2tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (8 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium

reproductive system
enlarged endometrial glands ( J:247103 )
• enlarged amorphic and cystic glands characteristic of aged endometrium




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory