All Phenotypes Tubb5<tm2.1Dak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tubb5^tm2.1Dak
targeted mutation 2.1, David A Keays
MGI:6119464

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tubb5^tm2.1Dak/Tubb5⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:6119481
cn2	Trp53^tm1Brn/Trp53^tm1Brn Tubb5^tm2.1Dak/Tubb5⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:6119482
cn3	Tubb5^tm2.1Dak/Tubb5^tm2.1Dak Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:6119483

Allelic Composition	Tubb5^tm2.1Dak/Tubb5⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Tubb5^tm2.1Dak mutation (1 available); any Tubb5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:240157 )

• at E14.5

decreased brain size ( J:240157 )

• with reduced cortex volume

decreased corpus callosum size ( J:240157 )

• reduced volume

abnormal putamen morphology ( J:240157 )

• reduced volume

small thalamus ( J:240157 )

• reduced volume

small hippocampus ( J:240157 )

• reduced volume

thin cerebral cortex ( J:240157 )

• at P0 and severely reduced in adulthood

• however, cortex thickness is normal at E12.5, E14.5 and E16.

small olfactory bulb ( J:240157 )

• reduced volume

abnormal cerebellar layer morphology ( J:240157 )

• loss of upper neuronal layer

• however, cortical architecture is preserved

small cerebellum ( J:240157 )

• reduced volume

cellular

increased neuron apoptosis ( J:240157 )

• at E14.5

growth/size/body

microcephaly ( J:240157 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microcephaly		DOID:10907		J:240157

Allelic Composition	Trp53^tm1Brn/Trp53^tm1Brn Tubb5^tm2.1Dak/Tubb5⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)
Tubb5^tm2.1Dak mutation (1 available); any Tubb5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:240157 )

N	• neuronal apoptosis observed in Tubb5^tm2.1Dak / Tubb5⁺ Tg(Nes-cre)1Kln mice is rescued

Allelic Composition	Tubb5^tm2.1Dak/Tubb5^tm2.1Dak Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Tubb5^tm2.1Dak mutation (1 available); any Tubb5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:240157 )

prenatal lethality, incomplete penetrance ( J:240157 )

nervous system

nervous system phenotype ( J:240157 )

cellular

abnormal mitosis ( J:240157 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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