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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-D1b-em5Dvs
endonuclease-mediated mutation 5, David V Serreze
MGI:6119467
Summary 4 genotypes


Genotype
MGI:6119570
cx1
Allelic
Composition		 H2-Ab1g7-em1Dvs/H2-Ab1g7-em1Dvs
H2-D1b-em5Dvs/H2-D1b-em5Dvs
H2-K1d-em1Dvs/H2-K1d-em1Dvs
Genetic
Background		 NOD/ShiLtDvs-H2-K1d-em1Dvs H2-Ab1g7-em1Dvs H2-D1em5Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1g7-em1Dvs mutation (1 available); any H2-Ab1 mutation (83 available)
H2-D1b-em5Dvs mutation (4 available); any H2-D1 mutation (47 available)
H2-K1d-em1Dvs mutation (4 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell subpopulation ratio ( J:257229 )
• in addition to the altered CD4+ and CD8+ numbers, there is a slight increase in the number of CD4/CD8 double negative and NKT cells relative to H2 class I null/class II intact mice
decreased alpha-beta T cell number ( J:257229 )
• only approximately 12% of splenocytes are Thy1.2+, and of these only 60% are alpha/beta T cells with an increase in percentage of gamma/delta T cells
• there are fewer splenic CD8+ T cells than in NOD controls but more than in histocompatibility class I null/class II intact mice
decreased CD4-positive, alpha-beta T cell number ( J:257229 )
• drastically reduced CD4+ splenocyte number

immune system
abnormal T cell subpopulation ratio ( J:257229 )
• in addition to the altered CD4+ and CD8+ numbers, there is a slight increase in the number of CD4/CD8 double negative and NKT cells relative to H2 class I null/class II intact mice
decreased alpha-beta T cell number ( J:257229 )
• only approximately 12% of splenocytes are Thy1.2+, and of these only 60% are alpha/beta T cells with an increase in percentage of gamma/delta T cells
• there are fewer splenic CD8+ T cells than in NOD controls but more than in histocompatibility class I null/class II intact mice
decreased CD4-positive, alpha-beta T cell number ( J:257229 )
• drastically reduced CD4+ splenocyte number
decreased susceptibility to autoimmune diabetes ( J:257229 )
• between 9 and 12 weeks of age no insulitis is found




Genotype
MGI:6119468
cx2
Allelic
Composition		 H2-D1b-em5Dvs/H2-D1b-em5Dvs
H2-K1d-em1Dvs/H2-K1d-em1Dvs
Genetic
Background		 NOD/ShiLtDvs-H2-K1d-em1Dvs H2-D1b-em5Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-em5Dvs mutation (4 available); any H2-D1 mutation (47 available)
H2-K1d-em1Dvs mutation (4 available); any H2-K1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell subpopulation ratio ( J:257229 )
• relative to beta 2 microglobulin null NOD mice these homozygotes have a slight increase in the number of splenic CD8 positive T cells

immune system
abnormal T cell subpopulation ratio ( J:257229 )
• relative to beta 2 microglobulin null NOD mice these homozygotes have a slight increase in the number of splenic CD8 positive T cells
decreased susceptibility to autoimmune diabetes ( J:257229 )
• resistant to insulitis and diabetes out to 30 days of age compared with wild-type NOD controls




Genotype
MGI:6119484
cx3
Allelic
Composition		 H2-D1b-em5Dvs/H2-D1b-em5Dvs
H2-K1d-em1Dvs/H2-K1d-em1Dvs
Tg(HLA-A/H2-D/B2M)1Dvs/?
Genetic
Background		 NOD/ShiLtDvs-H2-K1d-em1Dvs H2-D1b-em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-em5Dvs mutation (4 available); any H2-D1 mutation (47 available)
H2-K1d-em1Dvs mutation (4 available); any H2-K1 mutation (60 available)
Tg(HLA-A/H2-D/B2M)1Dvs mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

immune system
increased susceptibility to autoimmune diabetes ( J:257229 )
• despite the absence of endognenous MHC class I, female carriers of this transgene have insulitis and development of autoimmune diabetes comparable to that of wild-type NOD




Genotype
MGI:6119478
cx4
Allelic
Composition		 H2-D1b-em5Dvs/H2-D1b-em5Dvs
H2-K1d-em1Dvs/H2-K1d-em1Dvs
Tg(HLA-B39/H2-D/B2m)2Dvs/?
Genetic
Background		 NOD/ShiLtDvs-H2-K1d-em1Dvs H2-D1b-em5Dvs Tg(HLA-B39/H2-D/B2M)2Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-em5Dvs mutation (4 available); any H2-D1 mutation (47 available)
H2-K1d-em1Dvs mutation (4 available); any H2-K1 mutation (60 available)
Tg(HLA-B39/H2-D/B2m)2Dvs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

immune system
increased susceptibility to autoimmune diabetes ( J:257229 )
• despite the absence of endognenous MHC class I, female carriers of this transgene have insulitis and development of autoimmune diabetes comparable to that of wild-type NOD




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory