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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Orai1tm1Smua
targeted mutation 1, Shmuel Muallem
MGI:6119518
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua 		involves: BALB/c * C57BL/6J MGI:7625698
cn2
 		Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb 		involves: BALB/c * C57BL/6J * C57BL/6N MGI:7625702


Genotype
MGI:7625698
cn1
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Genetic
Background		 involves: BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Orai1tm1Smua mutation (0 available); any Orai1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:345485 )
N
• no defects in B cell development in the bone marrow or spleen
abnormal B cell physiology ( J:345485 )
• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%
• however, agonist induced Ca2+ oscillations are similar to controls
• residual SOCE activity is not inhibited by 2-aminoethyl diphenyl borate (2-APB)
• anti-IgM mediated NFAT1 translocation is significantly reduced
abnormal B cell activation ( J:345485 )
• following anti-IgM stimulation proliferation is similar to controls but cell viability is moderately reduced
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted

homeostasis/metabolism
abnormal calcium ion homeostasis ( J:345485 )
• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%
• residual SOCE activity in B cells is not inhibited by 2-aminoethyl diphenyl borate (2-APB)
• however, agonist induced Ca2+ oscillations in B cells are similar to controls

hematopoietic system
abnormal B cell physiology ( J:345485 )
• store-operated Ca2+ entry (SOCE) in B cells is reduced by~69%
• however, agonist induced Ca2+ oscillations are similar to controls
• residual SOCE activity is not inhibited by 2-aminoethyl diphenyl borate (2-APB)
• anti-IgM mediated NFAT1 translocation is significantly reduced
abnormal B cell activation ( J:345485 )
• following anti-IgM stimulation proliferation is similar to controls but cell viability is moderately reduced
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted




Genotype
MGI:7625702
cn2
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Orai1tm1Smua/Orai1tm1Smua
Orai3em1.1Treb/Orai3em1.1Treb
Genetic
Background		 involves: BALB/c * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Orai1tm1Smua mutation (0 available); any Orai1 mutation (22 available)
Orai3em1.1Treb mutation (0 available); any Orai3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:345485 )
N
• immune responses to influenza A infection are similar to controls
abnormal B cell physiology ( J:345485 )
• store-operated Ca2+ entry in B cells is reduced by~83%
• anti-IgM mediated NFAT1 translocation is significantly reduced
abnormal B cell activation ( J:345485 )
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted
decreased B cell proliferation ( J:345485 )
• decrease in both proliferation and viablity of cells following anti-IgM stimulation

hematopoietic system
abnormal B cell physiology ( J:345485 )
• store-operated Ca2+ entry in B cells is reduced by~83%
• anti-IgM mediated NFAT1 translocation is significantly reduced
abnormal B cell activation ( J:345485 )
• increase in oxygen consumption rate and extracellular acidification rates following B cell receptor activation is significantly blunted
decreased B cell proliferation ( J:345485 )
• decrease in both proliferation and viablity of cells following anti-IgM stimulation

homeostasis/metabolism
abnormal calcium ion homeostasis ( J:345485 )
• store-operated Ca2+ entry in B cells is reduced by~83%

cellular
decreased B cell proliferation ( J:345485 )
• decrease in both proliferation and viablity of cells following anti-IgM stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory