All Phenotypes Pdx1<tm1.1(flpo)Most> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdx1^{tm1.1(flpo)Most}
targeted mutation 1.1, Michael C Ostrowski
MGI:6119579

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	MGI:6273511
cn2	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6	MGI:6273512

Allelic Composition	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm5Tyj mutation (2 available); any Kras mutation (84 available)
Pdx1^{tm1.1(flpo)Most} mutation (0 available); any Pdx1 mutation (35 available)
Trp53^tm1.1Dgk mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 4.5 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs with only 2 mice showing liver metastasis

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• both low and high grade PanIN lesions are seen at 2-3 months of age, but by 6 months, invasive carcinoma is present

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550

Allelic Composition	Kras^tm5Tyj/Kras⁺ Pdx1^{tm1.1(flpo)Most}/Pdx1⁺ Trp53^tm1.1Dgk/Trp53^tm1.1Dgk
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * Black Swiss * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:248550 )

• mice exhibit a decrease in median survival time which is approximately 2 months of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• mice develop classical PanIN lesions that progress to invasive carcinoma

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:248550 )

• mice develop invasive pancreatic ductal adenocarcinoma

• however, mice show negligible metastasis to distant organs

increased pancreatic intraepithelial neoplasia incidence ( J:248550 )

• mice develop classical PanIN lesions that progress to invasive carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:248550

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24