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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tomm20em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:6120515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tomm20em1(IMPC)J/Tomm20em1(IMPC)J C57BL/6NJ-Tomm20em1(IMPC)J/Mmjax MGI:6394400
ht2
 		Tomm20em1(IMPC)J/Tomm20+ C57BL/6NJ-Tomm20em1(IMPC)J/Mmjax MGI:6288790


Genotype
MGI:6394400
hm1
Allelic
Composition		 Tomm20em1(IMPC)J/Tomm20em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Tomm20em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tomm20em1(IMPC)J mutation (2 available); any Tomm20 mutation (20 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Tomm20em1(IMPC)J/Tomm20em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts do not hatch from the zona pollucida or form outgrowths.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:290315 , J:279207 )
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture (J:279207)

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• normal looking blastocysts are present at E3.5 (15% versus 25%, n=26); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
failure of embryo implantation ( J:290315 , J:279207 )
• in vitro outgrowth assays show that blastocysts fail to hatch and do not form outgrowths after 3 days in culture (J:279207)




Genotype
MGI:6288790
ht2
Allelic
Composition		 Tomm20em1(IMPC)J/Tomm20+
Genetic
Background		 C57BL/6NJ-Tomm20em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tomm20em1(IMPC)J mutation (2 available); any Tomm20 mutation (20 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory