All Phenotypes Reep6<em2Ruch> MGI Mouse

oligozoospermia ( J:295354 )

teratozoospermia ( J:295354 )

asthenozoospermia ( J:295354 )

male infertility ( J:295354 )

impaired acrosome reaction ( J:295354 )

abnormal photoreceptor outer segment disc membrane morphology ( J:243288 )

• the stacking of the discs in the outer segment (OS) is slightly disoriented and non-uniform at P20 and by 6 months of age, photoreceptors are greatly reduced and disorganized, with shortened, fragmented OS

photoreceptor outer segment degeneration ( J:243288 )

• by 6 months of age, photoreceptors have shorted and fragmented outer segment

abnormal retina rod cell morphology ( J:243288 )

• expansion of the distal endoplasmic reticulum (near the base of the outer segment) in the rods

• increase in the number of mitochondria in the ellipsoid region of rods

retina photoreceptor degeneration ( J:243288 )

• mice exhibit progressive photoreceptor degeneration from P20 onwards

thin retina outer nuclear layer ( J:243288 )

• progressive thinning of the outer nuclear layer (ONL), with mild thinning at P20, severe thinning at 2 months, and only 40% of ONL rows remaining in the retina at 4 months of age

abnormal electroretinogram waveform feature ( J:243288 )

• electroretinograms show that photoreceptor dysfunction precedes degeneration

decreased a-wave amplitude ( J:243288 )

• full-field electroretinography of dark-adapted mice shows a reduction in the scotopic response to light as early as P20, with both the a-wave and b-wave amplitudes deceased and severely reduced amplitudes at 2 and 4 months of age

decreased b-wave amplitude ( J:243288 )