Phenotypes associated with this allele

• Allele Symbol: Tmprss6^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6120748
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss6^tm1b(EUCOMM)Wtsi/Tmprss6^tm1b(EUCOMM)Wtsi	C57BL/6N-Tmprss6^tm1b(EUCOMM)Wtsi/Ics	MGI:6263728

Genotype
MGI:6263728

hm1

• Allelic Composition: Tmprss6^{tm1b(EUCOMM)Wtsi}/Tmprss6^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Tmprss6^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0453_1_B07

Data Sources

IMPC Data for Tmprss6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - ICS

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - ICS

hematopoietic system

decreased hematocrit ( J:211773 )

♂

IMPC - ICS

decreased hemoglobin content ( J:211773 )

♂

IMPC - ICS

decreased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - ICS

decreased mean corpuscular hemoglobin concentration ( J:211773 )

♂

IMPC - ICS

decreased mean corpuscular volume ( J:211773 )

♂

IMPC - ICS

increased CD11b-high dendritic cell number ( J:211773 )

♂

IMPC - ICS

increased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - ICS

decreased NK cell number ( J:211773 )

♂

IMPC - ICS

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - ICS

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - ICS

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - ICS

increased circulating calcium level ( J:211773 )

IMPC - ICS

immune system

immune system phenotype ( J:211773 )

♀

IMPC - ICS

increased CD11b-high dendritic cell number ( J:211773 )

♂

IMPC - ICS

increased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - ICS

decreased NK cell number ( J:211773 )

♂

IMPC - ICS

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - ICS

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - ICS

integument

abnormal coat/ hair morphology ( J:211773 )

IMPC - ICS

abnormal coat appearance ( J:211773 )

IMPC - ICS

abnormal coat/hair pigmentation ( J:211773 )

IMPC - ICS

abnormal skin morphology ( J:211773 )

IMPC - ICS

limbs/digits/tail

short tibia ( J:211773 )

IMPC - ICS

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - ICS

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

IMPC - ICS

skeleton

short tibia ( J:211773 )

IMPC - ICS