All Phenotypes Vgll4<tm1b(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vgll4^{tm1b(EUCOMM)Hmgu}
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:6120802

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu}	C57BL/6N-Vgll4^{tm1b(EUCOMM)Hmgu}/Ieg	MGI:6263853
hm2	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu}	involves: C57BL/6N * CBA	MGI:6360906
ht3	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4⁺	C57BL/6N-Vgll4^{tm1b(EUCOMM)Hmgu}/Ieg	MGI:6263852
cn4	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0	involves: 129S4/SvJae * C57BL/6N * CBA * SJL	MGI:6360911
cn5	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL	MGI:6360909
cn6	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C57BL/6J * C57BL/6N * CBA/J * SJL	MGI:6360913
cn7	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Tg(Tek-cre)1Ywa/0	involves: C57BL/6N * CBA * SJL	MGI:6360907

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu}
Genetic Background	C57BL/6N-Vgll4^{tm1b(EUCOMM)Hmgu}/Ieg
Cell Lines	HEPD0680_7_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)

Data Sources

IMPC Data for Vgll4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1b(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:273437 )

• all mice die within 14 weeks of birth

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N	• at neonatal stages, mitral and tricuspid valves appear normal

abnormal heart development ( J:273437 )

• increased proliferation of valvar interstitial cells in E15.5 heart valves

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• at P1

thick aortic valve cusps ( J:273437 )

• at adult and neonatal stages

aortic valve stenosis ( J:273437 )

thick pulmonary valve cusps ( J:273437 )

• at adult and neonatal stages

abnormal blood flow velocity ( J:273437 )

• increased velocity and pressure gradient across the aortic valves

increased cardiac muscle contractility ( J:273437 )

• increased ejection fraction and fractional shortening

growth/size/body

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• at P1

decreased body size ( J:273437 )

• at P1

decreased body weight ( J:273437 )

• from birth

cellular

increased cell proliferation ( J:273437 )

• increased proliferation of valvar interstitial cells in E15.5 heart valves

muscle

increased cardiac muscle contractility ( J:273437 )

• increased ejection fraction and fractional shortening

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4⁺
Genetic Background	C57BL/6N-Vgll4^{tm1b(EUCOMM)Hmgu}/Ieg
Cell Lines	HEPD0680_7_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)

Data Sources

IMPC Data for Vgll4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased locomotor activity ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating lipase level ( J:211773 )

IMPC - HMGU

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S4/SvJae * C57BL/6N * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)
Vgll4^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Vgll4 mutation (24 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N	• hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)
Vgll4^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Vgll4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart development ( J:273437 )

• non-cell autonomous, enhanced proliferation of endothelial-derived valvar interstitial cells leading to valve thickening

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C57BL/6J * C57BL/6N * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)
Vgll4^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Vgll4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N	• neonatal and adult mice exhibit normal valves

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Tg(Tek-cre)1Ywa/0
Genetic Background	involves: C57BL/6N * CBA * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N	• neonatal mice exhibit normal capillary vessel distribution and endocardium

increased myocardial fiber size ( J:273437 )

• increased cross sectional area

abnormal heart development ( J:273437 )

• prolonged cell proliferation and reduced apoptosis of endothelial-derived valvar interstitial cells

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• severe at 36 weeks of age

thick aortic valve cusps ( J:273437 )

• at P0 and in adult mice

thick pulmonary valve cusps ( J:273437 )

• at P0 and in adult mice

increased heart left ventricle weight ( J:273437 )

cardiac fibrosis ( J:273437 )

decreased cardiac muscle contractility ( J:273437 )

• decreased ejection fraction and fractional shortening

cellular

decreased apoptosis ( J:273437 )

• reduced apoptosis of endothelial-derived valvar interstitial cells

increased cell proliferation ( J:273437 )

• prolonged cell proliferation of endothelial-derived valvar interstitial cells

muscle

increased myocardial fiber size ( J:273437 )

• increased cross sectional area

decreased cardiac muscle contractility ( J:273437 )

• decreased ejection fraction and fractional shortening

growth/size/body

increased heart weight ( J:273437 )

• relative to body weight

cardiac hypertrophy ( J:273437 )

• severe at 36 weeks of age

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