Phenotypes associated with this allele

• Allele Symbol: Nodal^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6120819
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nodal^tm1b(EUCOMM)Wtsi/Nodal^tm1b(EUCOMM)Wtsi	C57BL/6N-Nodal^tm1b(EUCOMM)Wtsi/H	MGI:6263032
ht2	Nodal^tm1b(EUCOMM)Wtsi/Nodal^+	C57BL/6N-Nodal^tm1b(EUCOMM)Wtsi/H	MGI:6263031

Genotype
MGI:6263032

hm1

• Allelic Composition: Nodal^{tm1b(EUCOMM)Wtsi}/Nodal^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Nodal^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0197_2_B12

Data Sources

IMPC Data for Nodal

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - HAR

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:6263031

ht2

• Allelic Composition: Nodal^{tm1b(EUCOMM)Wtsi}/Nodal⁺
• Genetic Background: C57BL/6N-Nodal^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0197_2_B12

Data Sources

IMPC Data for Nodal

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - HAR

decreased locomotor activity ( J:211773 )

♂

IMPC - HAR

cardiovascular system

cornea vascularization ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - HAR

increased circulating triglyceride level ( J:211773 )

♂

IMPC - HAR

vision/eye

cornea vascularization ( J:211773 )

IMPC - HAR