Phenotypes associated with this allele

• Allele Symbol: Trp53^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6120822
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1b(EUCOMM)Hmgu/Trp53^tm1b(EUCOMM)Hmgu	C57BL/6N-Trp53^tm1b(EUCOMM)Hmgu/H	MGI:6263778
ht2	Trp53^tm1b(EUCOMM)Hmgu/Trp53^+	C57BL/6N-Trp53^tm1b(EUCOMM)Hmgu/H	MGI:6263777

Genotype
MGI:6263778

hm1

• Allelic Composition: Trp53^{tm1b(EUCOMM)Hmgu}/Trp53^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Trp53^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0601_2_G11

Data Sources

IMPC Data for Trp53

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased startle reflex ( J:211773 )

♀

IMPC - HAR

hematopoietic system

increased large unstained cell number ( J:211773 )

♂

IMPC - HAR

immune system

increased large unstained cell number ( J:211773 )

♂

IMPC - HAR

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HAR

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - HAR

abnormal retina morphology ( J:211773 )

IMPC - HAR

Genotype
MGI:6263777

ht2

• Allelic Composition: Trp53^{tm1b(EUCOMM)Hmgu}/Trp53⁺
• Genetic Background: C57BL/6N-Trp53^{tm1b(EUCOMM)Hmgu}/H
• Cell Lines: HEPD0601_2_G11

Data Sources

IMPC Data for Trp53

homeostasis/metabolism

decreased circulating creatine kinase level ( J:211773 )

♀

IMPC - HAR