Phenotypes associated with this allele

• Allele Symbol: Strip1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6121053
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Strip1^tm1b(KOMP)Wtsi/Strip1^tm1b(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N * FVB/NJ	MGI:6121351
cn2	Strip1^tm1b(KOMP)Wtsi/Strip1^tm1c(KOMP)Wtsi Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: C57BL/6N * CBA * FVB/NJ * SJL	MGI:6121353

Genotype
MGI:6121351

hm1

• Allelic Composition: Strip1^{tm1b(KOMP)Wtsi}/Strip1^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/NJ
• Cell Lines: EPD0316_1_G03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal mesoderm development ( J:251816 )

• mesodermal and mesenchymal cells exhibit defects in actin organization, focal adhesions and migration compared with control cells

short rostral-caudal axis ( J:251816 )

• extremely shortened anterior-posterior axis lacking a trunk section at E8.5

abnormal primitive streak morphology ( J:251816 )

• swollen at E8.5

cellular

decreased fibroblast cell migration ( J:251816 )

• slower migration of mouse embryonic fibroblasts in a scratch assay compared with wild-type cells

Genotype
MGI:6121353

cn2

• Allelic Composition: Strip1^{tm1b(KOMP)Wtsi}/Strip1^{tm1c(KOMP)Wtsi}; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: C57BL/6N * CBA * FVB/NJ * SJL
• Cell Lines: EPD0316_1_G03

embryo

embryo phenotype ( J:251816 )

N • unlike Strip1 ^cin homozygotes, mice do not exhibit the constriction around the embryonic and extraembryonic tissue boundary, defects in cell proliferation, and organization and polarity of neural and epithelium

abnormal mesoderm development ( J:251816 )

• nascent mesoderm fails to move away from the primitive streak and accumulates in the midline ridge

short rostral-caudal axis ( J:251816 )

• extremely shortened anterior-posterior axis lacking a trunk section at E8.5

abnormal head fold morphology ( J:251816 )

cardiovascular system

cardia bifida ( J:251816 )