Analysis Tools
cellular
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• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice
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hematopoietic system
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• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice
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immune system
| N |
• populations of CD4+ cells in spleen and lymph nodes (LNs)
• numbers of CD4+ T cells in spleen and draining LNs during induction of EAE with MOG same as in similarly treated wild-type mice
• TCR usage in CD4+ T cells during induction of EAE with MOG same as in similarly treated wild-type mice
• CD4+ T cell proliferation and Il2, Cd44 and Cd25 expression during induction of EAE with MOG same as in similarly treated wild-type mice
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• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice
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• MOG (35-55) peptide-induced EAE
• encephalitogenic CD4+ T cells from MOG-treated mice cause earlier disease onset with higher clinical scores when transplanted into sub-lethally irradiated WT recipient mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| multiple sclerosis | DOID:2377 |
OMIM:612594 OMIM:612595 OMIM:612596 |
J:238772 | |
