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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spata18tm1.2Hifa
targeted mutation 1.2, Hirofumi Arakawa
MGI:6121375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		ApcMin/Apc+
Spata18tm1.2Hifa/Spata18tm1.2Hifa 		involves: C57BL/6J MGI:6121392
cx2
 		ApcMin/Apc+
Spata18tm1.2Hifa/Spata18+ 		involves: C57BL/6J MGI:6121393


Genotype
MGI:6121392
cx1
Allelic
Composition		 ApcMin/Apc+
Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Spata18tm1.2Hifa mutation (0 available); any Spata18 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:254117 )
• compared to Apc controls
increased classified tumor incidence ( J:254117 )
• compared to Apc controls
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine compared to Apc::Spata18 mutants and to Apc controls
increased colon adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential compared to Apc::Spata18 mutants

digestive/alimentary system
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine compared to Apc::Spata18 mutants and to Apc controls
increased colon adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential compared to Apc::Spata18 mutants
intestine polyps ( J:254117 )
• increased number compared to Apc controls
• significantly increased size compared to Apc controls

cellular
abnormal mitochondrial crista morphology ( J:254117 )
• substantial increase in nitrotyrosine and 8-OHdG immunoreactivity in small intestinal adenoma and adenocarcinoma tumors
• significant reduction in internal cristae density in small intestine mucosal epithelium and adenoma and adenocarcinoma tumor cells

hematopoietic system
anemia ( J:254117 )
• more severe compared to Apc controls, caused by increased intestinal hemorrhage

mortality/aging
premature death ( J:254117 )
• reduced lifespan, compared to Apc controls, as a result of severe anemia




Genotype
MGI:6121393
cx2
Allelic
Composition		 ApcMin/Apc+
Spata18tm1.2Hifa/Spata18+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Spata18tm1.2Hifa mutation (0 available); any Spata18 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:254117 )
• compared to Apc controls
increased classified tumor incidence ( J:254117 )
• compared to Apc controls
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine
increased colon adenoma incidence ( J:254117 )
• high grade adenoma

digestive/alimentary system
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine
increased colon adenoma incidence ( J:254117 )
• high grade adenoma
intestine polyps ( J:254117 )
• increased number compared to Apc controls
• significantly increased size compared to Apc controls

cellular
abnormal mitochondrial crista morphology ( J:254117 )
• substantial increase in nitrotyrosine and 8-OHdG immunoreactivity in small intestinal adenoma and adenocarcinoma tumors

hematopoietic system
anemia ( J:254117 )
• more severe compared to Apc controls, caused by increased intestinal hemorrhage

mortality/aging
premature death ( J:254117 )
• reduced lifespan, compared to Apc controls, as a result of severe anemia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory