About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spata18tm1.2Hifa
targeted mutation 1.2, Hirofumi Arakawa
MGI:6121375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		ApcMin/Apc+
Spata18tm1.2Hifa/Spata18tm1.2Hifa 		involves: C57BL/6J MGI:6121392
cx2
 		ApcMin/Apc+
Spata18tm1.2Hifa/Spata18+ 		involves: C57BL/6J MGI:6121393


Genotype
MGI:6121392
cx1
Allelic
Composition		 ApcMin/Apc+
Spata18tm1.2Hifa/Spata18tm1.2Hifa
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Spata18tm1.2Hifa mutation (0 available); any Spata18 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:254117 )
• compared to Apc controls
increased classified tumor incidence ( J:254117 )
• compared to Apc controls
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine compared to Apc::Spata18 mutants and to Apc controls
increased colon adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential compared to Apc::Spata18 mutants

digestive/alimentary system
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine compared to Apc::Spata18 mutants and to Apc controls
increased colon adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential compared to Apc::Spata18 mutants
intestine polyps ( J:254117 )
• increased number compared to Apc controls
• significantly increased size compared to Apc controls

cellular
abnormal mitochondrial crista morphology ( J:254117 )
• substantial increase in nitrotyrosine and 8-OHdG immunoreactivity in small intestinal adenoma and adenocarcinoma tumors
• significant reduction in internal cristae density in small intestine mucosal epithelium and adenoma and adenocarcinoma tumor cells

hematopoietic system
anemia ( J:254117 )
• more severe compared to Apc controls, caused by increased intestinal hemorrhage

mortality/aging
premature death ( J:254117 )
• reduced lifespan, compared to Apc controls, as a result of severe anemia




Genotype
MGI:6121393
cx2
Allelic
Composition		 ApcMin/Apc+
Spata18tm1.2Hifa/Spata18+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Spata18tm1.2Hifa mutation (0 available); any Spata18 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:254117 )
• compared to Apc controls
increased classified tumor incidence ( J:254117 )
• compared to Apc controls
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine
increased colon adenoma incidence ( J:254117 )
• high grade adenoma

digestive/alimentary system
increased small intestine adenocarcinoma incidence ( J:254117 )
• significantly increased cell proliferative potential
increased intestinal adenoma incidence ( J:254117 )
• high grade adenoma
• significantly increased cell proliferative potential in small intestine
increased colon adenoma incidence ( J:254117 )
• high grade adenoma
intestine polyps ( J:254117 )
• increased number compared to Apc controls
• significantly increased size compared to Apc controls

cellular
abnormal mitochondrial crista morphology ( J:254117 )
• substantial increase in nitrotyrosine and 8-OHdG immunoreactivity in small intestinal adenoma and adenocarcinoma tumors

hematopoietic system
anemia ( J:254117 )
• more severe compared to Apc controls, caused by increased intestinal hemorrhage

mortality/aging
premature death ( J:254117 )
• reduced lifespan, compared to Apc controls, as a result of severe anemia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory