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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lcn6tm1.1Ylzh
targeted mutation 1.1, Yonglian Zhang
MGI:6121435
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lcn6tm1.1Ylzh/Lcn6tm1.1Ylzh
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+ 		involves: 129S/SvEv * C57BL/6 MGI:6121436


Genotype
MGI:6121436
cn1
Allelic
Composition		 Lcn6tm1.1Ylzh/Lcn6tm1.1Ylzh
Ndor1Tg(UBC-cre/ERT2)1Ejb/Ndor1+
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcn6tm1.1Ylzh mutation (0 available); any Lcn6 mutation (21 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:256079 )
N
• after tamoxifen treatment fertility was not impaired and sperm fertilization ability, motility, and capacitation were similar to controls
abnormal sperm physiology ( J:256079 )
• sperm from tamoxifen treated males show elevated intracellular calcium levels
premature acrosome reaction ( J:256079 )
• sperm from tamoxifen treated males show enhanced spontaneous acrosome reaction frequencies when non-capacitated or capacitated for 1 h

homeostasis/metabolism
abnormal calcium ion homeostasis ( J:256079 )
• sperm from tamoxifen treated males show elevated intracellular calcium levels




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory