All Phenotypes Mirc34<tm1.1Pisc> MGI Mouse

increased susceptibility to bacterial infection induced morbidity/mortality ( J:256929 )

• opportunistic bacterial infection with gram-negative Pasteurella pneumotropica

• following treatment with a broad-spectrum antibiotic most mice survive

postnatal lethality, incomplete penetrance ( J:256929 )

• about 80% of mice die before 4 weeks of age typically from bacterial infections

• following treatment with a broad-spectrum antibiotic most mice survive and those that survive past 5 weeks have normal lifespan

decreased respiratory motile cilia number ( J:256929 )

• extent of ciliation in the nasal respiratory epithelium is severely reduced

• absence of normal ciliation in the trachea, bronchi, and bronchioles

• monociliated cells of the olfactory epithelium do not appear to be affected

nasal inflammation ( J:256929 )

• show severe inflammation in the nasal cavity

abnormal respiratory epithelium physiology ( J:256929 )

• increase in the fraction of proliferating cells

• increase in proliferating cells is inversely correlated with the decrease in ciliation

abnormal oviduct epithelium motile cilium morphology ( J:256929 )

• strong reduction in the number of multicilia

oligozoospermia ( J:256929 )

• strong reduction of sperm counts in the epididymis

abnormal seminiferous tubule morphology ( J:256929 )

• atrophy of the tubules is seen starting at 5 weeks of age

abnormal efferent ductules of testis morphology ( J:256929 )

• strong reduction in the number of multicilia

abnormal oviduct physiology ( J:256929 )

• increase in the fraction of proliferating cells in the epithelium

• increase in proliferating cells is inversely correlated with the decrease in ciliation

abnormal oviduct transport ( J:256929 )

• 2.5 days after superovulation oocytes remain trapped in the bursa of the ovary

female infertility ( J:256929 )

male infertility ( J:256929 )

• 7 of 8 males were incapable of impregnating wild-type females

postnatal growth retardation ( J:256929 )

• fail to thrive

slow postnatal weight gain ( J:256929 )

• following treatment with a broad-spectrum antibiotic most mice gain weight normally

nervous system phenotype ( J:256929 )

N	• consistent with expression patterns cilia of the brain ventricles do not appear to be affected

renal/urinary system phenotype ( J:256929 )

N	• consistent with expression patterns cilia of the kidney do not appear to be affected

neoplasm ( J:256929 )

N	• no signs of increased tumorigenesis are detected

abnormal oviduct epithelium motile cilium morphology ( J:256929 )

• strong reduction in the number of multicilia

decreased respiratory motile cilia number ( J:256929 )

• extent of ciliation in the nasal respiratory epithelium is severely reduced

• absence of normal ciliation in the trachea, bronchi, and bronchioles

• monociliated cells of the olfactory epithelium do not appear to be affected

oligozoospermia ( J:256929 )

• strong reduction of sperm counts in the epididymis

abnormal seminiferous tubule morphology ( J:256929 )

• atrophy of the tubules is seen starting at 5 weeks of age

nasal inflammation ( J:256929 )

• show severe inflammation in the nasal cavity

increased susceptibility to bacterial infection induced morbidity/mortality ( J:256929 )

• opportunistic bacterial infection with gram-negative Pasteurella pneumotropica

• following treatment with a broad-spectrum antibiotic most mice survive

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24