Phenotypes associated with this allele

• Allele Symbol: Tg(CD2-Lrch1)#Liux
• Allele Name: transgene insertion, Xiaolong Liu
• Allele ID: MGI:6121483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CD2-Lrch1)#Liux/0	involves: C57BL/6	MGI:6140062

Genotype
MGI:6140062

tg1

• Allelic Composition: Tg(CD2-Lrch1)#Liux/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular extravasation ( J:238772 )

• reduced migration of encephalitogenic CD4+ T cells from MOG-treated mice toward chemokine Cxcl12 in vitro

• reduced number of CD4+ cells in CNS after MOG peptide-induced experimental autoimmune encephalomyelitis

hematopoietic system

abnormal cellular extravasation ( J:238772 )

• reduced migration of encephalitogenic CD4+ T cells from MOG-treated mice toward chemokine Cxcl12 in vitro

• reduced number of CD4+ cells in CNS after MOG peptide-induced experimental autoimmune encephalomyelitis

immune system

immune system phenotype ( J:238772 )

N • numbers of CD4+ T cells in spleen and draining LNs during induction of EAE with MOG same as in similarly treated wild-type mice

abnormal cellular extravasation ( J:238772 )

• reduced migration of encephalitogenic CD4+ T cells from MOG-treated mice toward chemokine Cxcl12 in vitro

• reduced number of CD4+ cells in CNS after MOG peptide-induced experimental autoimmune encephalomyelitis

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:238772 )

• reduced clinical scores after MOG (35-55) peptide-induced EAE

• encephalitogenic CD4+ T cells from MOG-treated mice fail to cause disease when transplanted into sub-lethally irradiated WT recipient mice