All Phenotypes Cfap43<em1Pfr> MGI Mouse

teratozoospermia ( J:257803 )

• male homozygotes show a significantly increased proportion of morphologically abnormal spermatozoa

abnormal sperm flagellum morphology ( J:257803 )

• 100% of sperm exhibit short, thick, and coiled flagella

abnormal sperm axoneme morphology ( J:257803 )

• sperm axoneme is highly abnormal; the doublets of microtubules (DMTs) are completely disorganized and the central pair and head of the radial spoke interacting with the central pair are absent

abnormal sperm radial spoke morphology ( J:257803 )

• head of the radial spoke interacting with the central pair is absent

absent sperm axonemal central pair ( J:257803 )

thick sperm flagellum ( J:257803 )

coiled sperm flagellum ( J:257803 )

short sperm flagellum ( J:257803 )

• TEM revealed that the short sperm tail actually corresponds to a large cytoplasmic mass containing unorganized structural components of the flagellum

abnormal sperm head morphology ( J:257803 )

• sperm head is slightly deformed but shows an overall normal hooked form

immotile sperm ( J:257803 )

• sperm are completely immotile showing loss of both total and progressive motility

male infertility ( J:257803 )

• although epididymal sperm concentrations are within normal range, male homozygotes show complete sterility when mated with wild-type females

• in contrast, female homozygotes are fully fertile and produce litters of normal size