Analysis Tools
behavior/neurological
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• homozygotes show no significant differences in locomotor activity, fear learning and memory or object recognition memory relative to wild-type controls
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• in the elevated plus maze test, male (but not female) homozygotes spend significantly less time in the open arms than wild-type controls, indicating increased anxiety-like behavior
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• both male and female homozygotes spend a significantly longer time self-grooming than wild-type controls, indicating high spontaneous repetitive grooming behavior
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• in the marble burying test, male (but not female) homozygotes bury significantly more marbles than wild-type controls, indicating increased repetitive (burying) behavior
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• in the presence of female urine, male homozygotes make significantly fewer scent marks than wild-type and heterozygous males during a 5-min test session in the open field box, indicating impaired social communication
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• in the 3-chamber test, both male and female homozygotes show no preference for stranger 2 over stranger 1, whereas wild-type controls spend more time in the novel mouse chamber (stranger 2) than in the familiar mouse chamber (stranger 1)
• however, both male and female homozygotes spend significantly more time in the chamber with a stranger mouse than with a nonsocial novel object, indicating normal sociability
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:257371 | ||
