Phenotypes associated with this allele

• Allele Symbol: Nrros^tm1Wouy
• Allele Name: targeted mutation 1, Wenjun Ouyang
• Allele ID: MGI:6144005
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lyz2^tm1(cre)Ifo/Lyz2^tm1(cre)Ifo Nrros^tm1Wouy/Nrros^tm1Wouy	involves: 129P2/OlaHsd	MGI:6144087

Genotype
MGI:6144087

cn1

• Allelic Composition: Lyz2^tm1(cre)Ifo/Lyz2^tm1(cre)Ifo; Nrros^tm1Wouy/Nrros^tm1Wouy
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular extravasation ( J:209569 )

• increased migration into CNS in myelin oligodendrocyte glycoprotein MOG-CFA-induced EAE experiments

oxidative stress ( J:209569 )

• significantly increased ROS production from CNS-infiltrating leukocytes in MOG-CFA-induced EAE experiments

• significantly increased malondialdehyde levels in CNS tissue in MOG-CFA-induced EAE experiments

hematopoietic system

abnormal cellular extravasation ( J:209569 )

• increased migration into CNS in myelin oligodendrocyte glycoprotein MOG-CFA-induced EAE experiments

immune system

abnormal cellular extravasation ( J:209569 )

• increased migration into CNS in myelin oligodendrocyte glycoprotein MOG-CFA-induced EAE experiments

increased susceptibility to experimental autoimmune encephalomyelitis ( J:209569 )

• increased disease severity (lesions in central nervous system (CNS)) and high mortality in myelin oligodendrocyte glycoprotein (MOG)35-55-complete Freunds adjuvant (CFA)-induced EAE experiments

• when treated with reactive oxygen species (ROS) scavengers after EAE induction with MOG-CFA