Phenotypes associated with this allele

• Allele Symbol: Ciz1^tm1.1Homy
• Allele Name: targeted mutation 1.1, Hiroaki Honda
• Allele ID: MGI:6147606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ciz1^tm1.1Homy/Ciz1^tm1.1Homy	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:6147862

Genotype
MGI:6147862

cn1

• Allelic Composition: Ciz1^tm1.1Homy/Ciz1^tm1.1Homy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:198470 )

N • cell cycle and cell growth parameters of mouse embryo fibroblasts (MEFs)

N • DNA damage response (DDR) of MEFs to gamma-irradiation or radiomimetic drugs hydroxyurea and camptothecin

increased cellular sensitivity to hydroxyurea ( J:198470 )

• sensitive to replicative stress caused by low doses (0.1-0.4 mM) of hydroxyurea: significantly lower survival rate of treated MEFs compared to similarly treated wild-ty

• DNA damage response (DDR) of mouse embryo fibroblasts (MEFs) to high dose (5 mM) of radiomimetic drug hydroxyurea

embryo

embryo phenotype ( J:198470 )

N • no obvious phenotype regarding embryonic development; mice born in expected Mendelian ratios

endocrine/exocrine glands

thymus hyperplasia ( J:198470 )

• in some mice after neonatal infection with Moloney murine leukemia virus MOL4070A

growth/size/body

growth/size/body region phenotype ( J:198470 )

N • no obvious phenotype regarding postnatal growth

enlarged spleen ( J:198470 )

• after neonatal infection with Moloney murine leukemia virus MOL4070A

hematopoietic system

thymus hyperplasia ( J:198470 )

• in some mice after neonatal infection with Moloney murine leukemia virus MOL4070A

enlarged spleen ( J:198470 )

• after neonatal infection with Moloney murine leukemia virus MOL4070A

immune system

thymus hyperplasia ( J:198470 )

• in some mice after neonatal infection with Moloney murine leukemia virus MOL4070A

enlarged spleen ( J:198470 )

• after neonatal infection with Moloney murine leukemia virus MOL4070A

lymph node hyperplasia ( J:198470 )

• in some mice after neonatal infection with Moloney murine leukemia virus MOL4070A

neoplasm

increased tumor incidence following infection ( J:198470 )

• after neonatal infection with Moloney murine leukemia virus MOL4070A

• increased acute lymphoblastic leukemia (ALL) incidence in 7 of 10 mice

• increased acute myeloid leukemia (AML) incidence in 1 of 10 mice

• all mice develop leukemia within 1 year

• leukemic cells proliferated in peripheral blood and infiltrated liver, spleen, lymph nodes and other tissues

• acute undifferentiated leukemia (AUL) incidence in 1 of 10 mice