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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polrmttm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:6147647
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Polrmttm1.1Arte/Polrmttm1.1Arte
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6N * FVB MGI:6147657


Genotype
MGI:6147657
cn1
Allelic
Composition		 Polrmttm1.1Arte/Polrmttm1.1Arte
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polrmttm1.1Arte mutation (0 available); any Polrmt mutation (45 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:258184 )
• all die before 6 weeks of age

cardiovascular system
dilated cardiomyopathy ( J:258184 )
• progressive enlargement of the heart with dilation of the left ventricular chamber
decreased heart rate variability ( J:258184 )
• 40% reduction in heart rate variability in older mice

cellular
abnormal mitochondrial morphology ( J:258184 )
• disorganized cristae
abnormal mitochondrial physiology ( J:258184 )
• severe mitochondrial dysfunction in the heart of terminal stage mice

muscle
dilated cardiomyopathy ( J:258184 )
• progressive enlargement of the heart with dilation of the left ventricular chamber




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory