Phenotypes associated with this allele

• Allele Symbol: Slc5a5^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:6147653
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc5a5^tm1d(KOMP)Wtsi/Slc5a5^tm1d(KOMP)Wtsi	involves: C57BL/6 * FVB/N * SJL	MGI:6147662

Genotype
MGI:6147662

hm1

• Allelic Composition: Slc5a5^{tm1d(KOMP)Wtsi}/Slc5a5^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:250121 )

• when a minimal iodide diet

• however, mice fed a standard chow produce levels that trend towards an increase but not significantly

decreased circulating thyroxine level ( J:250121 )

• when fed standard chow or a minimal iodide diet

decreased circulating triiodothyronine level ( J:250121 )

• when a minimal iodide diet

• however, mice fed standard chow produce normal levels of T3

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:250121 )

• loss of follicular structure at 6 to 8 months

enlarged thyroid gland ( J:250121 )

cellular

abnormal redox activity ( J:250121 )

• mice fed a minimal iodine diet exhibit reduced production of hydrogen peroxide and free radicles in brown adipose tissue compared with control mice