All Phenotypes Cdh9<tm1b(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdh9^{tm1b(KOMP)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:6147663

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh9^{tm1b(KOMP)Wtsi}/Cdh9^{tm1b(KOMP)Wtsi}	C57BL/6N-Cdh9^{tm1b(KOMP)Wtsi}/Ics	MGI:6461138
cn2	Cdh9^{tm1b(KOMP)Wtsi}/Cdh9^{tm1b(KOMP)Wtsi} Kcng4^{tm1.1(cre)Jrs}/Kcng4⁺ Tg(Thy1-EYFP)15Jrs/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA * FVB/N	MGI:6147651
cn3	Cdh9^{tm1b(KOMP)Wtsi}/Cdh9^{tm1b(KOMP)Wtsi} Neto1^{tm1.1(cre)Jrs}/Neto1⁺ Tg(Thy1-EYFP)15Jrs/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA * FVB/N	MGI:6147652

Allelic Composition	Cdh9^{tm1b(KOMP)Wtsi}/Cdh9^{tm1b(KOMP)Wtsi}
Genetic Background	C57BL/6N-Cdh9^{tm1b(KOMP)Wtsi}/Ics
Cell Lines	EPD0837_1_F03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh9^{tm1b(KOMP)Wtsi} mutation (0 available); any Cdh9 mutation (46 available)

Data Sources

IMPC Data for Cdh9

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - ICS

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - ICS

Allelic Composition	Cdh9^{tm1b(KOMP)Wtsi}/Cdh9^{tm1b(KOMP)Wtsi} Kcng4^{tm1.1(cre)Jrs}/Kcng4⁺ Tg(Thy1-EYFP)15Jrs/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh9^{tm1b(KOMP)Wtsi} mutation (0 available); any Cdh9 mutation (46 available)
Kcng4^{tm1.1(cre)Jrs} mutation (1 available); any Kcng4 mutation (24 available)
Tg(Thy1-EYFP)15Jrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:214586 )

N	• axonal arbors in ON-OFF direction-selective ganglion cells (ooDSGC), starburst amacrine cells (SAC), rod bipolar cells (BC), type 3a OFF BC, tyrosine-hydroxylase-positive wide-field amacrine cells, and Vglut3-positive narrow-field amacrine cells

abnormal retina bipolar cell morphology ( J:214586 )

• one-third of BC5 cells bear monostratified axonal arbors displaced into outer half of inner plexiform layer (IPL)

• two-thirds of BC5 cells bear monostratified axonal arbors in normal sublamina

• BC5 cell axonal arbors bistratified: distributed between two sublaminae

vision/eye

vision/eye phenotype ( J:214586 )

N	• axonal arbors in ON-OFF direction-selective ganglion cells (ooDSGC), starburst amacrine cells (SAC), rod bipolar cells (BC), type 3a OFF BC, tyrosine-hydroxylase-positive wide-field amacrine cells, and Vglut3-positive narrow-field amacrine cells

abnormal retina bipolar cell morphology ( J:214586 )

• one-third of BC5 cells bear monostratified axonal arbors displaced into outer half of inner plexiform layer (IPL)

• two-thirds of BC5 cells bear monostratified axonal arbors in normal sublamina

• BC5 cell axonal arbors bistratified: distributed between two sublaminae

Allelic Composition	Cdh9^{tm1b(KOMP)Wtsi}/Cdh9^{tm1b(KOMP)Wtsi} Neto1^{tm1.1(cre)Jrs}/Neto1⁺ Tg(Thy1-EYFP)15Jrs/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh9^{tm1b(KOMP)Wtsi} mutation (0 available); any Cdh9 mutation (46 available)
Neto1^{tm1.1(cre)Jrs} mutation (1 available); any Neto1 mutation (42 available)
Tg(Thy1-EYFP)15Jrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:214586 )

N	• axonal arbors in retinal type 2 bipolar cells (BC2)

vision/eye

vision/eye phenotype ( J:214586 )

N	• axonal arbors in retinal type 2 bipolar cells (BC2)

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