Analysis Tools|
Allele Symbol Allele Name Allele ID |
Snrktm1Hxu targeted mutation 1, Haiyan Xu MGI:6147677 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased blood glucose levels
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• pups die by postnatal day 2
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• white adipose tissue (WAT) is decreased by 50% in subcutaneous tissue
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• white adipose tissue (WAT) is decreased by 40% in epididymal tissue and 50% in subcutaneous tissue
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• mitochondria density in BAT is decreased and has occasional ruptures of mitochondrial cristae
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• brown adipose tissue (BAT) mass is decreased by 33% and have with less lipid accumulation
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• crown-like structure found in WAT
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• body weight in males is similar to wild-type at 4 weeks, but decreases by 22 weeks
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• on high fat diet, mice exhibit higher fasting blood glucose levels, however, there are no differences in body or fat pad weight
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• triglyceride contents of epididymal and subcutaneous WAT is decreased
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• white adipose tissue (WAT) is decreased by 50% in subcutaneous tissue
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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