Analysis Tools
reproductive system
small testis
(
J:258202
)
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• testis size is significantly decreased relative to that in wild-type controls
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• testis weight is significantly lower than that in wild-type controls
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• rate of normal spermatogenesis is significantly reduced with 30/86 tubules observed in mutant testes versus 103/103 tubules in wild-type controls
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• only a few spermatozoa are detected in the tubules of the caput and cauda epididymides, unlike in wild-type controls
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• 7% of spermatozoa extracted from the cauda epididymis show abnormal head and tail morphology
• however, globozoospermia is not observed
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• differentiation of round spermatids into mature spermatozoa is impaired
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• almost all cells extracted from the cauda epididymis are arrested at the round spermatid stage
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• adult male homozygotes are completely infertile due to a spermiogenic arrest
• mating behavior, ejaculation, and vaginal plug formation are normal
• female fertility is normal
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cellular
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• only a few spermatozoa are detected in the tubules of the caput and cauda epididymides, unlike in wild-type controls
|
|
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• 7% of spermatozoa extracted from the cauda epididymis show abnormal head and tail morphology
• however, globozoospermia is not observed
|
endocrine/exocrine glands
small testis
(
J:258202
)
|
|
• testis size is significantly decreased relative to that in wild-type controls
|
|
|
• testis weight is significantly lower than that in wild-type controls
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| male infertility | DOID:12336 | J:258202 | ||
