mortality/aging
• mice are born dead or die within hours after birth indicating perinatal lethality
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growth/size/body
• embryos are approximately 20% smaller from E10.5
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• approximately 20% smaller
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embryo
• embryos are approximately 20% smaller from E10.5
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immune system
• mice show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes
• however, no inflammation is seen in various tissues, including the brain
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• mouse embryo fibroblasts are highly refractory to vesicular stomatitis virus infection
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nervous system
N |
• no abnormalities are seen in the brain
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