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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rnaseh2atm1Crh
targeted mutation 1, Robert J Crouch
MGI:6147721
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rnaseh2atm1Crh/Rnaseh2atm1Crh Not Specified MGI:6274936
cx2
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Sting1tm1Gnb/Sting1tm1Gnb
involves: 129P2/OlaHsd MGI:6274938
cx3
Rag2tm1Fwa/Rag2tm1Fwa
Rnaseh2atm1Crh/Rnaseh2atm1Crh
involves: 129S/SvEv MGI:6274937
cx4
Cgastm1a(EUCOMM)Hmgu/Cgastm1a(EUCOMM)Hmgu
Rnaseh2atm1Crh/Rnaseh2atm1Crh
involves: C57BL/6N MGI:6274941
cx5
Mavstm1Zjc/Mavstm1Zjc
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Not Specified MGI:6274939


Genotype
MGI:6274936
hm1
Allelic
Composition
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2atm1Crh mutation (0 available); any Rnaseh2a mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are born dead or die within hours after birth indicating perinatal lethality

growth/size/body
• embryos are approximately 20% smaller from E10.5
• approximately 20% smaller

embryo
• embryos are approximately 20% smaller from E10.5

immune system
• mice show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes
• however, no inflammation is seen in various tissues, including the brain
• mouse embryo fibroblasts are highly refractory to vesicular stomatitis virus infection

nervous system
N
• no abnormalities are seen in the brain




Genotype
MGI:6274938
cx2
Allelic
Composition
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Sting1tm1Gnb/Sting1tm1Gnb
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2atm1Crh mutation (0 available); any Rnaseh2a mutation (46 available)
Sting1tm1Gnb mutation (0 available); any Sting1 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are either perinatal lethal or survive after birth; survival is at 6% of expected frequency with 2% of pups surviving weaning

growth/size/body
• surviving mice are about 70% in body size and weight compared to controls
• surviving mice are about 70% in body size and weight compared to controls

pigmentation
• white patches show lack of melanin in hair shafts
• however, skin histology from white patches in normal
• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life

cellular
• E13.5 and E15.5 embryos exhibit increased LINE-1 retroelement DNA levels in cytosolic extract, however, no elevation in L1 ORF1 protein is seen

integument
• white patches show lack of melanin in hair shafts
• however, skin histology from white patches in normal
• all viable mice present a ventral white spotting phenotype and white hind- and forepaws from birth which remains through life

reproductive system
• mice fail to produce offspring

immune system
N
• no abnormalities or inflammation in internal organs, including the brain, are seen in viable mice and expression of interferon-stimulated genes is restored to normal levels




Genotype
MGI:6274937
cx3
Allelic
Composition
Rag2tm1Fwa/Rag2tm1Fwa
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Rnaseh2atm1Crh mutation (0 available); any Rnaseh2a mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6274941
cx4
Allelic
Composition
Cgastm1a(EUCOMM)Hmgu/Cgastm1a(EUCOMM)Hmgu
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cgastm1a(EUCOMM)Hmgu mutation (1 available); any Cgas mutation (24 available)
Rnaseh2atm1Crh mutation (0 available); any Rnaseh2a mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• expression of interferon-stimulated genes is restored to normal levels




Genotype
MGI:6274939
cx5
Allelic
Composition
Mavstm1Zjc/Mavstm1Zjc
Rnaseh2atm1Crh/Rnaseh2atm1Crh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mavstm1Zjc mutation (1 available); any Mavs mutation (36 available)
Rnaseh2atm1Crh mutation (0 available); any Rnaseh2a mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
• E14.5 mouse embryo fibroblasts show increased expression of interferon-stimulated genes indicating innate immune activation of IFN-stimulated genes





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory