Analysis Tools
adipose tissue
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• inguinal adipocytes are smaller in size than controls
• however, in mice fed high fat diet (HFD) the size of visceral adipocytes is similar in both mutant and controls
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• increased amount of epididymal fat
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behavior/neurological
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• HFD-fed mice do not exhibit an impaired freeze response in the fear conditioning assay unlike HFD-fed controls
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cellular
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• decrease in crown-like structures formed by macrophages in visceral adipose tissue of mice fed HFD as compared to HFD-fed controls
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growth/size/body
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• decrease in body weight in 5-7 month old mice as compared to controls
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• decrease in snout-anus length
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• delay in fat accumulation on high fat diet (HFD) as compared to controls
• delay in relative loss of lean mass in first 6 weeks of HFD
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hematopoietic system
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• decrease in crown-like structures formed by macrophages in visceral adipose tissue of mice fed HFD as compared to HFD-fed controls
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homeostasis/metabolism
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• delay in fat accumulation on high fat diet (HFD) as compared to controls
• delay in relative loss of lean mass in first 6 weeks of HFD
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• glucose levels are lower in HFD-fed mice as compared to HFD-fed controls
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• insulin levels are lower in HFD-fed mice as compared to HFD-fed controls
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• HDL levels are increased in HFD-fed mice as compared to HFD-fed controls
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• total cholesterol levels are lower in both HFD-fed mice and CD-fed mice as compared to controls
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• LDL cholesterol levels are lower in HFD-fed mice as compared to HFD-fed controls
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• triglyceride levels are lower in HFD-fed mice as compared to HFD-fed controls
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immune system
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• decrease in crown-like structures formed by macrophages in visceral adipose tissue of mice fed HFD as compared to HFD-fed controls
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nervous system
