Phenotypes associated with this allele

• Allele Symbol: Adamts18^tm1.1Wzha
• Allele Name: targeted mutation 1.1, Wei Zhang
• Allele ID: MGI:6148036
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts18^tm1.1Wzha/Adamts18^tm1.1Wzha	involves: 129 * C57BL/6	MGI:6148038

Genotype
MGI:6148038

hm1

• Allelic Composition: Adamts18^tm1.1Wzha/Adamts18^tm1.1Wzha
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:258487 )

• increased intestinal inflammation and mucosal dysplasia in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

increased incidence of tumors by chemical induction ( J:258487 )

• increased incidence rate and tumor numbers following treatment with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

digestive/alimentary system

decreased colon goblet cell number ( J:258487 )

• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

decreased colon length ( J:258487 )

• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

increased susceptibility to induced colitis ( J:258487 )

• in a DSS-induced model mice show severe bloody stools, significant weight loss, and shorter colon lengths

growth/size/body

decreased body size ( J:258487 )

• seen in a substantial fraction of mice

respiratory system

overexpanded pulmonary alveolus ( J:258487 )

• seen in a substantial fraction of mice

vision/eye

abnormal eye development ( J:258487 )

• seen in a substantial fraction of mice

immune system

increased susceptibility to induced colitis ( J:258487 )

• in a DSS-induced model mice show severe bloody stools, significant weight loss, and shorter colon lengths

increased acute inflammation ( J:258487 )

• increased intestinal inflammation in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

endocrine/exocrine glands

decreased colon goblet cell number ( J:258487 )

• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

neoplasm

increased incidence of tumors by chemical induction ( J:258487 )

• increased incidence rate and tumor numbers following treatment with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls

cellular

decreased colon goblet cell number ( J:258487 )

• in mice treated with azoxymethane and 3 rounds of dextran sodium sulfate compared to similarly treated controls