About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp949tm1Htno
targeted mutation 1, Masahiko Hatano
MGI:6149131
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp949tm1Htno/Zfp949tm1Htno involves: 129S1/Sv * 129X1/SvJ MGI:6152407
cx2
 		Cdkn1btm1Kin/Cdkn1btm1Kin
Zfp949tm1Htno/Zfp949tm1Htno 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:6152408


Genotype
MGI:6152407
hm1
Allelic
Composition		 Zfp949tm1Htno/Zfp949tm1Htno
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp949tm1Htno mutation (0 available); any Zfp949 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:259302 )
• no viable mice are found after E10.5
embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:259302 )
• fewer than expected mice are present at E8.5 and E9.5

embryo
abnormal embryo development ( J:259302 )
• at E8.5 and E9.5
decreased embryo size ( J:259302 )
• at E6.5, E7.5, E8.5 and E9.5
abnormal neural plate morphology ( J:259302 )
• disorganized and generally hypocellularity at E9.5

growth/size/body
embryonic growth retardation ( J:259302 )
decreased embryo size ( J:259302 )
• at E6.5, E7.5, E8.5 and E9.5

cellular

nervous system
abnormal neural plate morphology ( J:259302 )
• disorganized and generally hypocellularity at E9.5




Genotype
MGI:6152408
cx2
Allelic
Composition		 Cdkn1btm1Kin/Cdkn1btm1Kin
Zfp949tm1Htno/Zfp949tm1Htno
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Kin mutation (1 available); any Cdkn1b mutation (26 available)
Zfp949tm1Htno mutation (0 available); any Zfp949 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:259302 )
• fewer than expected mice are present at E9.5, E10.5 and E11.5
• no mice are recovered after E11.5

embryo
abnormal embryo turning ( J:259302 )
• some turning at E10.5

growth/size/body
decreased embryo size ( J:259302 )

cellular
decreased cell proliferation ( J:259302 )
• not as severe as in Zfp949tm1Htno homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory