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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp15tm1Pgrs
targeted mutation 1, Phillippe Gross
MGI:6149705
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp15tm1Pgrs/Usp15tm1Pgrs Not Specified MGI:6149722
ht2
 		Usp15L749R/Usp15tm1Pgrs involves: 129S1/SvImJ * C57BL/6J MGI:6149723


Genotype
MGI:6149722
hm1
Allelic
Composition		 Usp15tm1Pgrs/Usp15tm1Pgrs
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15tm1Pgrs mutation (0 available); any Usp15 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are mostly (85% survival) resistant to fatal encephalitis unlike wild-type mice

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are mostly (85% survival) resistant to fatal encephalitis unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are mostly (85% survival) resistant to fatal encephalitis unlike wild-type mice




Genotype
MGI:6149723
ht2
Allelic
Composition		 Usp15L749R/Usp15tm1Pgrs
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp15L749R mutation (0 available); any Usp15 mutation (60 available)
Usp15tm1Pgrs mutation (0 available); any Usp15 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice

immune system
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice
decreased susceptibility to parasitic infection induced morbidity/mortality ( J:259382 )
• in an experimental cerebral malaria model, mice infected with Plasmodium berghei Anka strain (PbA) are resistant (95% survival) to fatal encephalitis unlike wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory