Phenotypes associated with this allele

• Allele Symbol: Arv1^tm1.2Radr
• Allele Name: targeted mutation 1.2, Daniel J Rader
• Allele ID: MGI:6149717
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arv1^tm1.2Radr/Arv1^tm1.2Radr	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:6149752

Genotype
MGI:6149752

hm1

• Allelic Composition: Arv1^tm1.2Radr/Arv1^tm1.2Radr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased fatty acid oxidation ( J:241193 )

♀ • 66% increased whole-body fatty acid oxidation rate after a 24-h fast

adipose tissue

adipose tissue phenotype ( J:241193 )

N • normal brown adipose tissue (BAT) weight

decreased subcutaneous adipose tissue amount ( J:241193 )

• at age 12 weeks

decreased white adipose tissue amount ( J:241193 )

• decreased perigonadal WAT at age 12 weeks

• more intense cytoplasmic hematoxylin and eosin staining and dramatically smaller white adipocytes in inguinal subcutaneous, perigonadal, mesenteric and perirenal WAT

decreased body fat mass ( J:241193 )

• reduced by 44%

decreased white fat cell size ( J:241193 )

• in inguinal subcutaneous, perigonadal, mesenteric and perirenal WAT

decreased percent body fat/body weight ( J:241193 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:241193 )

♂N • normal plasma insulin levels after fasting 4 hours

increased fatty acid oxidation ( J:241193 )

♀ • 66% increased whole-body fatty acid oxidation rate after a 24-h fast

decreased fasting circulating glucose level ( J:241193 )

♂ • lower blood glucose in males after fasting 4 hours

♂ • normal fasting glucose levels in females

hypoglycemia ( J:241193 )

• ~1 out of 6 mice after overnight fasting

decreased circulating leptin level ( J:241193 )

♂ • after fasting 4 hours

abnormal circulating lipid level ( J:241193 )

• 15% reduced plasma total cholesterol levels

• 17% reduced plasma HDL-C levels

• plasma non-HDL-C and triglyceride levels

decreased circulating cholesterol level ( J:241193 )

• 15% reduced plasma total cholesterol levels

decreased circulating HDL cholesterol level ( J:241193 )

• 17% reduced plasma HDL-C levels

increased carbon dioxide production ( J:241193 )

• during light cycle

increased oxygen consumption ( J:241193 )

• during light cycle

decreased respiratory quotient ( J:241193 )

• moderately lower respiratory quotient (RQ) during dark cycle

• normal respiratory quotient (RQ) during light cycle

improved glucose tolerance ( J:241193 )

♂ • area-under-curve (AUC) reduced by 45% in intraperitoneal glucose tolerance test after 16 h overnight fast

increased circulating adiponectin level ( J:241193 )

♂ • after fasting 4 hours

increased basal metabolism ( J:241193 )

• more energy expenditure (calculated heat) during light cycle

abnormal lipid metabolism ( J:241193 )

♀ • increased fat tolerance after oral olive oil lavage after overnight fast

growth/size/body

growth/size/body region phenotype ( J:241193 )

N • normal liver, heart, lungs, spleen, kidney and brain weights at age 12 weeks

N • normal body length at age 4-6 months in males

N • normal total bone mineral content at age 4-6 months in males

decreased body fat mass ( J:241193 )

• reduced by 44%

decreased lean body mass ( J:241193 )

• reduced by 20%

slow postnatal weight gain ( J:241193 )

• on standard chow or high-fat diet

• normal weight at time of weaning

mortality/aging

decreased survivor rate ( J:241193 )

• decreased survivability: ~30% of mice died by 5 months

moribund ( J:241193 )

• ~1 out of 6 mice after overnight fasting

premature death ( J:241193 )

• increased susceptibility to spontaneous death in adulthood (3-6 months): ~30% of mice died by 5 months

behavior/neurological

behavior/neurological phenotype ( J:241193 )

N • normal water intake

increased food intake ( J:241193 )

• during light cycle

hyperactivity ( J:241193 )

• during light cycle

integument

decreased subcutaneous adipose tissue amount ( J:241193 )

• at age 12 weeks

liver/biliary system

liver/biliary system phenotype ( J:241193 )

N • normal hepatic triglyceride levels

cardiovascular system

poor circulation ( J:241193 )

• ~1 out of 6 mice mice cold to touch after overnight fasting

reproductive system

female infertility ( J:241193 )

♀