Phenotypes associated with this allele

• Allele Symbol: Zfp106^em1Blk
• Allele Name: endonuclease-mediated mutation 1, Brian L Black
• Allele ID: MGI:6149784
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp106^em1Blk/Zfp106^em1Blk	Not Specified	MGI:6150429

Genotype
MGI:6150429

hm1

• Allelic Composition: Zfp106^em1Blk/Zfp106^em1Blk
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:241305 )

• in quadriceps muscles

• increased variation in fiber size

• very few centrally located nuclei

skeletal muscle fiber atrophy ( J:241305 )

• extensive, at 3 months of age

• grouped atrophy in quadriceps muscles

skeletal muscle fiber degeneration ( J:241305 )

• significantly reduced number of choline-acetyltransferase-positive motor neurons in spinal cord at 8 weeks of age

behavior/neurological

abnormal physical strength ( J:241305 )

• reduced muscle strength from 4 weeks of age in all mice

decreased grip strength ( J:241305 )

• from 4 weeks of age in all mice

nervous system

decreased motor neuron number ( J:241305 )

• significantly reduced number of choline-acetyltransferase-positive motor neurons in spinal cord at 8 weeks of age

growth/size/body

cachexia ( J:241305 )

• due to muscle wasting